A tire structure for a bicycle includes a tire body having an outer periphery, and a tread integrally formed on the outer periphery of the tire body. The tread includes an inner layer having a first color, and an outer layer coated on the inner layer and having a second color different from the first color. The outer layer formed with a plurality of openings, thereby exposing the inner layer outward from the outer layer through the plurality of openings. In such a manner, the inner layer and the outer layer of the tread present at least two different colors, thereby increasing the aesthetic quality of the tire structure of the bicycle.