发明申请
- 专利标题： Cycloalkyl substituted polyamines for cancer therapy and methods of synthesis therefor
- 专利标题（中）： 用于癌症治疗的环烷基取代多胺及其合成方法
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申请号： US10313530申请日： 2002-12-06
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公开(公告)号： US20030195377A1公开(公告)日： 2003-10-16
- 发明人: Benjamin Frydman , Aldonia L. Valasinas , Andrei V. Blokhin , Aparajita Sarkar , Hirak S. Basu , Venodhar K. Reddy , Laurence J. Marton , Yu Wang
- 申请人： SLIL Biomedical Corporation
- 申请人地址： WI Madison
- 专利权人： SLIL Biomedical Corporation
- 当前专利权人： SLIL Biomedical Corporation
- 当前专利权人地址： WI Madison
- 主分类号： C07C211/17
- IPC分类号： C07C211/17
摘要：
Conformationally restricted polyamine compounds useful in treatment of cancer and other diseases marked by abnormal cell proliferation are disclosed. Improved methods of synthesizing such compounds are also disclosed. In one method of the invention, a carbene-bearing or carbene equivalent-bearing compound is reacted with the double bond of an alkene compound to form a cyclopropyl ring as the first step in the synthesis.
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