Low-cost, potentially disposable, hazardous material handling and anti-contamination hoods are described, that provide a very high level of protection of either personnel, in the case of a hazardous material handling hood, or the process contained in the hood in the case of an anti-contamination hood. Once contaminated these hoods can be hermetically sealed to contain the contamination so that the hood can be moved or shipped for disposal or analysis of the contaminants prior to disposal.