发明申请
- 专利标题： Process for the preparation of thiazole intermediate
- 专利标题（中）： 制备噻唑中间体的方法
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申请号： US10309812申请日： 2002-12-05
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公开(公告)号： US20030204095A1公开(公告)日： 2003-10-30
- 发明人: Pandurang Balwant Deshpande , Parven Kumar Luthra , Rajesh Vyas , Ramakrishna Kamma
- 申请人： Orchid Chemicals & Pharmaceuticals Limited
- 申请人地址： IN Chennai
- 专利权人： Orchid Chemicals & Pharmaceuticals Limited
- 当前专利权人： Orchid Chemicals & Pharmaceuticals Limited
- 当前专利权人地址： IN Chennai
- 优先权： IN325/MAS/2002 20020426
- 主分类号： C07D277/56
- IPC分类号： C07D277/56
摘要：
The present invention provides a process for the preparation of 4-methyl-5-formyl-thiazole of the formula (I) 1 which comprises reducing the thiazole ester of the formula (III) to thiazole alcohol of the formula (IV), using sodium borohydride in the presence of AlCl3 in a solvent and oxidising using an oxidizing agent the thiazole alcohol of the formula (IV) to obtain 4-methyl-5-formyl-thiazole of the formula (I).
公开/授权文献
- US06833459B2 Process for the preparation of thiazole intermediate 公开/授权日：2004-12-21
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