- 专利标题: New linear cyclic ureas
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申请号: US10369860申请日: 2003-02-20
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公开(公告)号: US20030229100A1公开(公告)日: 2003-12-11
- 发明人: Jean-Louis Peglion , Christophe Poitevin , Jean-Paul Vilaine , Nicole Villeneuve , Marie-Pierre Bourguignon , Catherine Thollon
- 优先权: FR99.16701 19991230
- 主分类号: A61K031/496
- IPC分类号: A61K031/496 ; A61K031/4709 ; C07D45/14
摘要:
Compound of formula (I): 1 wherein: V represents a single bond or an alkylene chain, M represents a single bond or an alkylene chain, A and E each represents nitrogen or CH, but at least one of the two groups A or E represents nitrogen, W represents a group of formula (i), (ii) or (iii): 2 wherein: X represents carbonyl, sulphonyl or sulphoxide, G1, G2 and G3 are as defined in the description, T represents a fused phenyl group or a fused pyridyl group, R1 represents hydrogen, linear or branched (C1-C6)alkyl, aryl or aryl-(C1-C6)alkyl in which the alkyl moiety is linear or branched, R2a and R2b, which are the same or different, are as defined in the description, R3 represents aryl or heteroaryl-A as defined in the description, each of which groups may optionally be substituted, Y represents aryloxy, heteroaryloxy or heteroaryl-B as defined in the description, each of which groups may optionally be substituted, its isomers, its hydrates, its solvates and addition salts thereof with a pharmaceutically acceptable acid. Medicinal products containing the same which are useful in the treatment of diseases or pathological conditions in which endothelial dysfunction is known.
公开/授权文献
- US06903103B2 Linear cyclic ureas 公开/授权日:2005-06-07
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