Apparatuses and methods are described for administering a needle-less injection of a degassed fluid. Prior to filling, or after filling but prior to administration of a needle-less injection, gas is removed from the fluid. A needle-less injection may then be performed with a reduced risk of discomfort to the recipient of the injection and with lower potential for the creation of a subdermal hematoma as a result of the injection. A wide variety of needle-less injectors may be used in accordance with various embodiments of the present invention.