公开(公告)号：US20020056486A1

公开(公告)日：2002-05-16

申请号：US10034561

申请日：2001-12-26

申请人： PENJET CORPORATION

发明人： Thomas P. Castellano

IPC分类号： B65B003/04 ,  B65B001/04

CPC分类号： A61J1/2096 ,  A61J1/062 ,  A61M5/1782 ,  A61M5/2046 ,  A61M5/2053 ,  A61M5/286 ,  A61M5/30 ,  A61M2005/2013 ,  A61M2005/2073 ,  A61M2005/3104 ,  A61M2005/31516

摘要： A device for storing and mixing an injectate includes a fluid holder removably coupled to an ampoule. The fluid holder initially contains a fluid and the ampoule initially contains a dry reagent. A breakable membrane may be included between the fluid holder and ampoule to prevent the undesirable mixing of the fluid with the dry reagent. Upon application of force to a plunger rod disposed within the fluid holder, fluid is introduced into the ampoule wherein it is mixed with the dry reagent to create an injectable mixture. Air or gas present in the ampoule may be removed therefrom; the fluid holder may be decoupled from the ampoule; and the ampoule may be further coupled to a needle-less injector for administration of an injection of the mixture. The device is particularly useful for lyophilized pharmaceuticals that rapidly lose medicinal efficacy once in solution form.

摘要翻译： 用于储存和混合注射剂的装置包括可移除地联接到安瓿的流体保持器。 流体保持器最初包含流体，并且安瓿最初含有干试剂。 可以在流体保持器和安瓿之间包括可破坏的膜，以防止流体与干试剂的不期望的混合。 当向设置在流体保持器内的柱塞杆施加力时，将流体引入安瓿中，其中其与干试剂混合以产生可注射混合物。 存在于安瓿中的空气或气体可以从其中移除; 流体保持器可以与安瓿去耦; 并且安瓿可以进一步联接到无针注射器以用于给予混合物的注射。 该装置对于以溶液形式快速失去药用功效的冻干药物特别有用。

公开(公告)号：US20040035491A1

公开(公告)日：2004-02-26

申请号：US10227885

申请日：2002-08-26

申请人： PenJet Corporation

发明人： Thomas P. Castellano

IPC分类号： B65B031/00 ,  B65B003/04 ,  B67C003/00 ,  B65B001/04

CPC分类号： A61M5/30 ,  A61M5/204 ,  A61M5/2053 ,  A61M5/2448 ,  A61M5/484 ,  A61M2005/2013 ,  A61M2005/2073 ,  A61M2205/50

摘要： Apparatuses and methods are described for administering a needle-less injection of a degassed fluid. Prior to filling, or after filling but prior to administration of a needle-less injection, gas is removed from the fluid. A needle-less injection may then be performed with a reduced risk of discomfort to the recipient of the injection and with lower potential for the creation of a subdermal hematoma as a result of the injection. A wide variety of needle-less injectors may be used in accordance with various embodiments of the present invention.

摘要翻译： 描述了用于无针注射脱气流体的装置和方法。 在填充之前或填充之后但在注射无针注射之前，从流体中除去气体。 然后可以以降低注射接受者不舒适的风险进行无针注射，并且作为注射的结果产生皮下血肿的可能性较低。 根据本发明的各种实施例，可以使用各种无针注射器。

公开(公告)号：US20020161334A1

公开(公告)日：2002-10-31

申请号：US10134511

申请日：2002-04-25

申请人： PENJET CORPORATION

发明人： Thomas P. Castellano ,  Roger R. Wise ,  Seth D. Levy

IPC分类号： A61M005/00

CPC分类号： A61J1/2096 ,  A61J1/2044 ,  A61J1/2089 ,  A61M5/30

摘要： Devices and methods are described for filling or refilling a needle-less injector. A coupling device is attached to a vessel, and mated to the dispensing end of a needle-less injector. A volume of fluid may be transferred via the coupling device, from the vessel to the injector. Air may be removed from the injector prior to the injector, vessel, and coupling device being separated from one another. In alternate embodiments, the vessel may include filling equipment capable of filling or refilling multiple needle-less injectors simultaneously, in series, or both. In other embodiments, a coupling device may be used to withdraw a fluid from a storage vial into a vessel for filling a needle-less injector. A storage vial may alternately contain a product, and a fluid may be introduced therein via a coupling device to create a mixture, which may be subsequently withdrawn into a vessel for filling a needle-less injector.

摘要翻译： 描述了用于填充或重新注射无针注射器的装置和方法。 联接装置附接到容器，并且配合到无针注射器的分配端。 一定体积的流体可以通过联接装置从容器传递到注射器。 在注射器，容器和联接装置彼此分离之前，空气可以从注射器移除。 在替代实施例中，容器可以包括能够同时，串联或两者填充或重新填充多个无针注射器的填充设备。 在其它实施例中，联接装置可以用于将流体从储存小瓶中取出到用于填充无针注射器的容器中。 存储小瓶可以交替地容纳产品，并且可以通过耦合装置将流体引入其中以产生混合物，其可以随后被抽出到用于填充无针注射器的容器中。

公开(公告)号：US20030083612A1

公开(公告)日：2003-05-01

申请号：US10227879

申请日：2002-08-26

申请人： PenJet Corporation

发明人： Thomas P. Castellano

IPC分类号： A61M005/30

CPC分类号： A61M5/30 ,  A61M5/2053 ,  A61M2005/2073

摘要： A needle-less injector suitable for injecting fluid through a surface includes a housing, a driver, an engine and a trigger. The housing contains a fluid and the engine contains a compressed gas. Upon application of sufficient force to the trigger, the compressed gas is released from the engine forcing the driver through the interior of the housing, expelling the liquid from the housing at a speed sufficient to pierce an injection surface. In one embodiment, the needle-less injector includes a mechanism for mitigating the kickback associated with releasing compressed gas from the engine. In another embodiment, the housing includes finger rests that provide stability and resistance to activate the device. In another embodiment, the engine is fitted with a reusable valve. In another embodiment, a safety clamp is included on the housing, preventing accidental activation of the device.

摘要翻译： 适用于通过表面喷射流体的无针注射器包括壳体，驱动器，发动机和触发器。 壳体包含流体，发动机含有压缩气体。 当向触发器施加足够的力时，压缩气体从发动机释放，迫使驾驶员穿过壳体的内部，以足以刺穿注射表面的速度从壳体排出液体。 在一个实施例中，无针注射器包括用于减轻与从发动机释放压缩气体相关联的反冲的机构。 在另一个实施例中，壳体包括提供稳定性和阻力以启动装置的手指支架。 在另一个实施例中，发动机装配有可重复使用的阀。 在另一个实施例中，壳体上包括安全夹，防止装置的意外启动。

公开(公告)号：US20020151841A1

公开(公告)日：2002-10-17

申请号：US10099846

申请日：2002-03-15

申请人： PENJET CORPORATION

发明人： Thomas P. Castellano

IPC分类号： A61M005/30

CPC分类号： A61M5/30 ,  A61M5/2053 ,  A61M2005/2073

摘要： An engine with a valve suitable for containing compressed gas and expelling the same upon opening of the valve is provided. Upon application of sufficient force to an element of the valve, the compressed gas is released from the engine. In one embodiment, the engine is fitted with a reusable valve. In another embodiment, the engine includes an engine housing with a pop-out feature that indicates if the engine is critically overcharged. A method of implementing quality control schemes during the manufacture or production of the engine and its component parts is provided, as well as a method of filling the engine with a compressed gas.

摘要翻译： 提供了一种具有适于容纳压缩气体并在阀打开时将其排出的阀的发动机。 当向阀的元件施加足够的力时，压缩气体从发动机释放。 在一个实施例中，发动机装配有可重复使用的阀。 在另一个实施例中，发动机包括具有弹出特征的发动机壳体，其指示发动机是否严重过充电。 提供了在制造或生产发动机及其部件期间实施质量控制方案的方法，以及用压缩气体填充发动机的方法。