发明申请
US20050004048A1 Methods and compositions for the manufacture of C-3' and C-4' anthracycline antibiotics
有权
用于制造C-3'和C-4'蒽环类抗生素的方法和组合物
- 专利标题： Methods and compositions for the manufacture of C-3' and C-4' anthracycline antibiotics
- 专利标题（中）： 用于制造C-3'和C-4'蒽环类抗生素的方法和组合物
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申请号： US10752426申请日： 2004-01-06
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公开(公告)号： US20050004048A1公开(公告)日： 2005-01-06
- 发明人: Waldeman Priebe , Izabella Fokt , Teresa Przewloka , Marta Krawczyk , Piotr Skibicki , Grzegorz Grynkiewicz , Roman Perez-Soler
- 申请人： Waldeman Priebe , Izabella Fokt , Teresa Przewloka , Marta Krawczyk , Piotr Skibicki , Grzegorz Grynkiewicz , Roman Perez-Soler
- 主分类号： C07H15/252
- IPC分类号： C07H15/252 ; A61K31/704 ; C07H15/24
摘要：
The present invention discloses new and novel substituted anthracyclines with modified alkyl-aromatic ring substitutions on the C-3′ of the sugar moiety or modified or unmodified alkyl-aromatic ring substitutions at the C-4′ of the sugar moiety. It also discloses novel methods for the preparation of sugar substrates and methods for the preparation of anthracyline antibiotics. These anthracycline analogs show high cytotoxicity in vitro against several tumor cell lines.
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