-
公开(公告)号：US07109177B2
公开(公告)日：2006-09-19
申请号：US10752426
申请日：2004-01-06
申请人： Waldeman Priebe , Izabella Fokt , Teresa Przewloka , Marta Krawczyk , Piotr Skibicki , Grzegorz Grynkiewicz , Roman Perez-Soler
发明人： Waldeman Priebe , Izabella Fokt , Teresa Przewloka , Marta Krawczyk , Piotr Skibicki , Grzegorz Grynkiewicz , Roman Perez-Soler
CPC分类号： C07H15/252 , A61K31/704
摘要： The present invention discloses new and novel substituted anthracyclines with modified alkyl-aromatic ring substitutions on the C-3′ of the sugar moiety or modified or unmodified alkyl-aromatic ring substitutions at the C-4′ of the sugar moiety. It also discloses novel methods for the preparation of sugar substrates and methods for the preparation of anthracycline antibiotics. These anthracycline analogs show high cytotoxicity in vitro against several tumor cell lines.
-
2.发明授权Methods and compositions for the manufacture of halogenated anthracyclines with increased antitumor activity, other anthracyclines, halogenated sugars, and glycosyl donors 失效用于制备具有增加的抗肿瘤活性的卤代蒽环类抗生素的方法和组合物，其它蒽环类，卤代糖和糖基供体公开(公告)号：US06355784B1
公开(公告)日：2002-03-12
申请号：US09330226
申请日：1999-06-10
申请人： Waldemar Priebe , Marta Krawczyk , Piotr Skibicki , Izabela Fokt , Krzysztof Dziewiszek , Grzegorz Grynkiewicz , Roman Perez-Soler
发明人： Waldemar Priebe , Marta Krawczyk , Piotr Skibicki , Izabela Fokt , Krzysztof Dziewiszek , Grzegorz Grynkiewicz , Roman Perez-Soler
IPC分类号： C07H1524
CPC分类号： C07H15/252
摘要： The present invention discloses new and novel halogenated anthracyclines linked through the saccharide portions. These congeners show high activity in vitro against several tumor cell lines. In doxorubicin (DOX) sensitive cell lines, they are at least as cytotoxic as DOX and in some cases more so. Many of these 4′- and 6′-fluorinated anthracyclines are more effective against multidrug-resistant tumors than was DOX, and/or have greater effectiveness than DOX against DOX sensitive cells. The compounds of this invention also have anti-amyloidogenic effects and the use of these compounds in the treatment of Alzheimer's disease is contemplated.
摘要翻译： 本发明公开了通过糖部分连接的新型和新型卤代蒽环类。 这些同系物在体外对几种肿瘤细胞系显示出高活性。 在多柔比星（DOX）敏感细胞系中，它们至少与DOX一样具有细胞毒性，在某些情况下更为如此。 这些4'-和6'-氟化蒽环类药物中的许多对抗多药耐药肿瘤比DOX更有效，和/或比DOX对DOX敏感细胞具有更大的效力。 本发明的化合物还具有抗淀粉样变性作用，并且考虑这些化合物在治疗阿尔茨海默氏病中的用途。
-
公开(公告)号：US07557090B2
公开(公告)日：2009-07-07
申请号：US11496976
申请日：2006-08-01
申请人： Waldemar Priebe , Izabella Fokt , Teresa Prezewloka , Marta Krawczyk , Piotr Skibicki , Grzegorz Grynkiewicz , Roman Perez-Soler
发明人： Waldemar Priebe , Izabella Fokt , Teresa Prezewloka , Marta Krawczyk , Piotr Skibicki , Grzegorz Grynkiewicz , Roman Perez-Soler
IPC分类号： A61K31/70
CPC分类号： C07H15/252 , A61K31/704
摘要： The present invention discloses new and novel substituted anthracyclines with modified alkyl-aromatic ring substitutions on the C-3′ of the sugar moiety or modified or unmodified alkyl-aromatic ring substitutions at the C-4′ of the sugar moiety. It also discloses novel methods for the preparation of sugar substrates and methods for the preparation of anthracycline antibiotics. These anthracycline analogs show high cytotoxicity in vitro against several tumor cell lines.
摘要翻译： 本发明公开了在糖部分的C-3'上具有改性的烷基 - 芳环取代的新的和新的取代的蒽环类，或在糖部分的C-4'被修饰或未修饰的烷基 - 芳环取代。 它还公开了制备糖底物的新方法和制备蒽环类抗生素的方法。 这些蒽环霉素类似物在体外对几种肿瘤细胞系显示高细胞毒性。
-
4.发明申请Methods and compositions for the manufacture of C-3' and C-4' anthracycline antibiotics 有权用于制造C-3'和C-4'蒽环类抗生素的方法和组合物公开(公告)号：US20070037758A1
公开(公告)日：2007-02-15
申请号：US11496976
申请日：2006-08-01
申请人： Waldemar Priebe , Izabella Fokt , Teresa Prezewloka , Marta Krawczyk , Piotr Skibicki , Grzegorz Grynkiewicz , Roman Perez-Soler
发明人： Waldemar Priebe , Izabella Fokt , Teresa Prezewloka , Marta Krawczyk , Piotr Skibicki , Grzegorz Grynkiewicz , Roman Perez-Soler
IPC分类号： C07H15/24 , A61K31/704
CPC分类号： C07H15/252 , A61K31/704
摘要： The present invention discloses new and novel substituted anthracyclines with modified alkyl-aromatic ring substitutions on the C-3′ of the sugar moiety or modified or unmodified alkyl-aromatic ring substitutions at the C-4′ of the sugar moiety. It also discloses novel methods for the preparation of sugar substrates and methods for the preparation of anthracycline antibiotics. These anthracycline analogs show high cytotoxicity in vitro against several tumor cell lines.
摘要翻译： 本发明公开了在糖部分的C-3'上具有改性的烷基 - 芳环取代的新的和新的取代的蒽环类，或在糖部分的C-4'被修饰或未修饰的烷基 - 芳环取代。 它还公开了制备糖底物的新方法和制备蒽环类抗生素的方法。 这些蒽环霉素类似物在体外对几种肿瘤细胞系显示高细胞毒性。
-
5.发明申请Methods and compositions for the manufacture of C-3' and C-4' anthracycline antibiotics 有权用于制造C-3'和C-4'蒽环类抗生素的方法和组合物公开(公告)号：US20050004048A1
公开(公告)日：2005-01-06
申请号：US10752426
申请日：2004-01-06
申请人： Waldeman Priebe , Izabella Fokt , Teresa Przewloka , Marta Krawczyk , Piotr Skibicki , Grzegorz Grynkiewicz , Roman Perez-Soler
发明人： Waldeman Priebe , Izabella Fokt , Teresa Przewloka , Marta Krawczyk , Piotr Skibicki , Grzegorz Grynkiewicz , Roman Perez-Soler
IPC分类号： C07H15/252 , A61K31/704 , C07H15/24
CPC分类号： C07H15/252 , A61K31/704
摘要： The present invention discloses new and novel substituted anthracyclines with modified alkyl-aromatic ring substitutions on the C-3′ of the sugar moiety or modified or unmodified alkyl-aromatic ring substitutions at the C-4′ of the sugar moiety. It also discloses novel methods for the preparation of sugar substrates and methods for the preparation of anthracyline antibiotics. These anthracycline analogs show high cytotoxicity in vitro against several tumor cell lines.
摘要翻译： 本发明公开了在糖部分的C-3'上具有改性的烷基 - 芳环取代的新的和新的取代的蒽环类，或在糖部分的C-4'被修饰或未修饰的烷基 - 芳环取代。 它还公开了制备糖底物的新方法和制备蒽环类抗生素的方法。 这些蒽环霉素类似物在体外对几种肿瘤细胞系显示高细胞毒性。
-
6.发明授权Methods and compositions for the manufacture of C-3′ and C-4′ anthracycline antibiotics 有权用于制造C-3'和C-4'蒽环类抗生素的方法和组合物公开(公告)号：US06673907B2
公开(公告)日：2004-01-06
申请号：US09956588
申请日：2001-09-19
申请人： Waldemar Priebe , Izabella Fokt , Teresa Przewloka , Marta Krawczyk , Piotr Skibicki , Grzegorz Grynkiewicz , Roman Perez-Soler
发明人： Waldemar Priebe , Izabella Fokt , Teresa Przewloka , Marta Krawczyk , Piotr Skibicki , Grzegorz Grynkiewicz , Roman Perez-Soler
IPC分类号： C07H100
CPC分类号： C07H15/252 , A61K31/704
摘要： The present invention discloses new and novel substituted anthracyclines with modified alkyl-aromatic ring substitutions on the C-3′ of the sugar moiety or modified or unmodified alkyl-aromatic ring substitutions at the C-4′ of the sugar moiety. It also discloses novel methods for the preparation of sugar substrates and methods for the preparation of anthracycline antibiotics. These anthracycline analogs show high cytotoxicity in vitro against several tumor cell lines.
摘要翻译： 本发明公开了在糖部分的C-3'上具有改性的烷基 - 芳环取代的新的和新的取代的蒽环类，或在糖部分的C-4'被修饰或未修饰的烷基 - 芳环取代。 它还公开了制备糖底物的新方法和制备蒽环类抗生素的方法。 这些蒽环霉素类似物在体外对几种肿瘤细胞系显示高细胞毒性。
-
7.发明授权Anthracyclines with unusually high activity against cells resistant to doxorubicin and its analogs 失效蒽环类药物对抗多柔比星及其类似物的细胞具有异常高的活性
公开(公告)号：US5625043A
公开(公告)日：1997-04-29
申请号：US396290
申请日：1995-02-27
IPC分类号： C07H15/252 , C07M15/24
CPC分类号： C07H15/252
摘要： The present disclosure details novel modified anthracyclines, the synthesis thereof, and their use in treating patients with tumors. Preferred aspects of the disclosure involve modified anthracyclines which have an O-substituted aromatic ring on their sugar moiety. Other preferred aspects of the disclosure involve synthesis steps wherein a hydroxyl group on a sugar moiety to be added is blocked with a halo-substituted alkyl group during the process of adding it to an anthracycline ring compound.
摘要翻译： 本发明详述了新型改性蒽环类药物的合成及其在治疗肿瘤患者中的用途。 本公开的优选方面涉及在其糖部分上具有O-取代的芳环的修饰的蒽环类。 本公开的其它优选方面涉及其中待添加的糖部分上的羟基在其加入蒽环类化合物的过程中被卤代烷基取代的合成步骤。
-
-
-
-
-
-
搜索结果
7 条记录 (耗时 0.014 秒)
