发明申请
- 专利标题: Pyrazole compounds useful as protein kinase inhibitors
- 专利标题(中): 用作蛋白激酶抑制剂的吡唑化合物
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申请号: US09952878申请日: 2001-09-14
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公开(公告)号: US20050004110A1公开(公告)日: 2005-01-06
- 发明人: David Bebbington , Hayley Binch , Ronald Knegtel , Julian Golec , Sanjay Patel , Jean- Damien Charrier , David Kay , Robert Davies
- 申请人: David Bebbington , Hayley Binch , Ronald Knegtel , Julian Golec , Sanjay Patel , Jean- Damien Charrier , David Kay , Robert Davies
- 主分类号: C07D403/12
- IPC分类号: C07D403/12 ; A61K31/415 ; A61K31/437 ; A61K31/4709 ; A61K31/4725 ; A61K31/501 ; A61K31/5025 ; A61K31/506 ; A61K31/517 ; A61K31/519 ; A61K31/52 ; A61K31/53 ; A61K31/5377 ; A61K31/541 ; A61K31/55 ; A61K45/00 ; A61P1/16 ; A61P3/08 ; A61P3/10 ; A61P3/14 ; A61P5/00 ; A61P9/00 ; A61P9/10 ; A61P11/06 ; A61P17/06 ; A61P19/00 ; A61P19/02 ; A61P19/10 ; A61P25/18 ; A61P25/28 ; A61P29/00 ; A61P31/12 ; A61P35/00 ; A61P35/02 ; A61P37/02 ; A61P37/06 ; A61P37/08 ; A61P43/00 ; C07D239/26 ; C07D239/36 ; C07D239/70 ; C07D239/88 ; C07D401/12 ; C07D401/14 ; C07D403/14 ; C07D405/14 ; C07D407/14 ; C07D409/14 ; C07D413/14 ; C07D417/14 ; C07D471/04 ; C07D473/16 ; C07D475/10 ; C07D487/04 ; C07D491/04 ; C07D491/044 ; C07D491/048 ; C07D491/052 ; C07D491/107 ; C07D491/113 ; C07D491/20 ; C07D493/04 ; C07D495/04 ; C07D498/04 ; C07D513/04 ; C07D521/00 ; C07
摘要:
This invention describes novel pyrazole compounds of formula III: wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; Rx and Ry are taken together with their intervening atoms to form a fused, unsaturated or partially unsaturated, 5-8 membered carbocyclo ring; and R2 and R2′ are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of aurora-2 and GSK-3, for treating diseases such as cancer, diabetes and Alzheimer's disease.
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