发明申请
US20050004153A1 Spiro-hydantoin compounds useful as anti-inflammatory agents
审中-公开
螺 - 乙内酰脲化合物可用作抗炎剂
- 专利标题： Spiro-hydantoin compounds useful as anti-inflammatory agents
- 专利标题（中）： 螺 - 乙内酰脲化合物可用作抗炎剂
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申请号： US10869292申请日： 2004-06-16
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公开(公告)号： US20050004153A1公开(公告)日： 2005-01-06
- 发明人: T.G. Dhar , Dominique Potin , Magali Blandine Maillet , Michele Launay , Eric Nicolai , Edwin Iwanowicz
- 申请人： T.G. Dhar , Dominique Potin , Magali Blandine Maillet , Michele Launay , Eric Nicolai , Edwin Iwanowicz
- 主分类号： C07D233/76
- IPC分类号： C07D233/76 ; A61K31/4166 ; A61K31/4184 ; A61K31/4188 ; A61K31/4192 ; A61K31/4196 ; A61K31/42 ; A61K31/427 ; A61K31/428 ; A61K31/4439 ; A61K31/454 ; A61K31/4545 ; A61K31/4709 ; A61K31/497 ; A61K31/498 ; A61K31/501 ; A61K31/506 ; A61K31/5377 ; A61K31/541 ; A61P1/00 ; A61P1/04 ; A61P1/16 ; A61P1/18 ; A61P3/10 ; A61P7/00 ; A61P9/00 ; A61P9/10 ; A61P11/00 ; A61P11/08 ; A61P13/12 ; A61P17/00 ; A61P17/06 ; A61P19/02 ; A61P19/10 ; A61P25/00 ; A61P25/28 ; A61P27/02 ; A61P27/16 ; A61P29/00 ; A61P37/02 ; A61P37/06 ; A61P37/08 ; A61P39/02 ; C07D233/96 ; C07D235/02 ; C07D401/04 ; C07D401/14 ; C07D487/10 ; C07D487/20 ; C07D519/00 ; A61K31/4747
摘要：
Compounds having the formula (I), and pharmaceutically-acceptable salts, hydrates, enantiomers, and diastereomers, and prodrugs thereof, are useful as inhibitors of LFA-1/ICAM and as anti-inflammatory agents, wherein L and K are O or S; Z is N or CR4b; Ar is an optionally-substituted aryl or heteroaryl; G is a linker attached to T or M or is absent; J, M and T are selected to define a three to six membered saturated or partially unsaturated non-aromatic ring; and R2, R4a, R4b, and R4c are as defined in the specification.
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