公开(公告)号：US12215108B2

公开(公告)日：2025-02-04

申请号：US18095429

申请日：2023-01-10

Applicant: Southern Research Institute ,  UAB Research Foundation ,  The United States Government as represented by the Department of Veterans Affairs

Inventor： Mark J. Suto ,  Bini Mathew ,  Corinne E. Augelli-Szafran ,  Marina Fosso Yatchang ,  Mohammad Athar ,  Anupam Agarwal ,  Ritesh Kumar Srivastava ,  Suhail Muzaffar ,  Jasim Khan

IPC: C07D473/32 ,  A61P39/02

Abstract: The present disclosure is concerned with purine diamine compounds for the treatment of conditions associated with BRD4, RIP3K, and/or IL6 signaling dysfunction such as, for example, cancer (e.g., lung cancer, skin cancer, bladder cancer, kidney cancer, liver cancer), arsenicosis, arsenic poisoning, inflammation, skin lesions, dysfunction of systemic organs, and skin blisters. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

公开(公告)号：US20240325431A1

公开(公告)日：2024-10-03

申请号：US18741818

申请日：2024-06-13

Applicant: BEACON MEDCARE (HK) LIMITED

Inventor： Chen JIANG ,  Tao SUN

IPC: A61K31/718 ,  A61K31/79 ,  A61K33/00 ,  A61K33/08 ,  A61K33/44 ,  A61M1/16 ,  A61M1/28 ,  A61P7/08 ,  A61P39/02 ,  B01J20/08 ,  B01J20/10 ,  B01J20/14 ,  B01J20/20 ,  B01J20/26 ,  B01J20/28

CPC classification number: A61K31/718 ,  A61K31/79 ,  A61K33/00 ,  A61K33/08 ,  A61K33/44 ,  A61M1/1654 ,  A61M1/287 ,  A61P7/08 ,  A61P39/02 ,  B01J20/08 ,  B01J20/103 ,  B01J20/14 ,  B01J20/20 ,  B01J20/264 ,  B01J20/267 ,  B01J20/28059 ,  B01J20/28061 ,  B01J20/28064 ,  B01J20/2808 ,  B01J20/28083 ,  B01J20/28085 ,  B01J20/28088

Abstract: Disclosed is a composition for the purification of biofluids, for example, for hemodialysis and peritoneal dialysis, comprising an osmotic agent and a toxin-removal reagent, wherein the toxin-removal reagent can remove a toxin from a biofluid under a condition for osmosis. Provided are a dialysis solution and a kit comprising the aforementioned composition, a method for removing a toxin from a biofluid using the aforementioned composition, and a method for treating a toxin-related disease.

公开(公告)号：US20240316123A1

公开(公告)日：2024-09-26

申请号：US18616811

申请日：2024-03-26

Applicant: ZBiotics Company

Inventor： Zachary Abbott

IPC: A61K35/742 ,  A61K9/00 ,  A61K35/00 ,  A61K35/741 ,  A61K38/00 ,  A61P39/02 ,  C07K14/32 ,  C12N9/02 ,  C12N15/63

CPC classification number: A61K35/742 ,  A61K9/0053 ,  A61P39/02 ,  C07K14/32 ,  C12N9/0008 ,  C12N15/63 ,  C12Y102/01003 ,  A61K9/0095 ,  A61K2035/115 ,  A61K35/741 ,  A61K38/00

Abstract: Provided herein are recombinant microorganisms that express a subject polypeptide. Microorganisms can comprise an expression construct comprising a flagellin promoter operatively linked with a heterologous nucleotide sequence encoding the subject polypeptide. The flagellin promoter sequence can comprise a genetic modification that reduces CsrA inhibition of translation. Microorganisms also can comprise a genetic modification that reduces FlgM inhibition of SigD initiation of transcription. The target polypeptide can be an aldehyde dehydrogenase. Such microorganisms are useful in the treatment of alcohol hangover.

公开(公告)号：US12054480B2

公开(公告)日：2024-08-06

申请号：US17392191

申请日：2021-08-02

Applicant: MAKScientific, LLC

Inventor： Alexandros Makriyannis ,  Kiran Vemuri

IPC: C07D417/12 ,  A61P39/02 ,  C07D205/04 ,  C07D207/273 ,  C07D231/14

CPC classification number: C07D417/12 ,  A61P39/02 ,  C07D205/04 ,  C07D207/273 ,  C07D231/14

Abstract: The present invention relates to novel compounds that can act as antidotes for treating “Acute Cannabinoid Overdose” produced by classical cannabinoids such as Δ9-tetrahydrocannabinol (THC) and several synthetic psychoactive cannabinoids (SPCs). The cannabis constituent THC exerts its psychotropic effects via CB1 receptor activation and SPCs mimic the effects of THC with higher potency and severe neurotoxicity. Compounds disclosed in this invention, their enantiomers, diastereomers, geometric isomers, racemates, tautomers, rotamers, atropisomers, metabolites, N-oxides, salts, solvates, hydrates, isotopic variations and their polymorphic forms can be therapeutically useful in an emergency setting for counteracting the intoxicating effects of acute THC ingestion and SPC overdose. Also, aspects of the invention are concerned with pyrazoles, imidazoles, triazoles, thiazoles, oxazoles, dihydropyrazoles, pyrrolidinones, azetidines, oxyazetidines and azaspiro[3.3]heptanes with unique pharmacokinetic and pharmacodynamic properties for treating “Acute Cannabinoid Overdose”.

公开(公告)号：US11918555B2

公开(公告)日：2024-03-05

申请号：US17552967

申请日：2021-12-16

Applicant: NEW FRONTIER LABS, LLC

Inventor： Robert T. Streeper ,  Elzbieta Izbicka

IPC: A61K31/23 ,  A61P39/02

CPC classification number: A61K31/23 ,  A61P39/02

Abstract: The disclosure provides compositions and methods of treating diseases and conditions associated with phospholipase D (PLD) toxin. In particular, the methods include administering to a subject in need a pharmaceutical composition comprising a dicarboxylic acid ester.

公开(公告)号：US20230357212A1

公开(公告)日：2023-11-09

申请号：US18044850

申请日：2021-09-10

Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  Etat francaisç, Service de Santé des Armées représenté par le délégué général de l'armement ,  Université de Strasbourg

Inventor： Rachid BAATI ,  Mallikarjuna Reddy NIMMAKAYALA ,  José DIAS ,  Florian NACHON ,  Camille VOROS ,  Raymond Franck RAZAFINDRAINIBE

IPC: C07D519/00 ,  A61P39/02 ,  C07D409/06 ,  C07D407/06

CPC classification number: C07D409/06 ,  A61P39/02 ,  C07D407/06 ,  C07D519/00

Abstract: The present invention relates to a compound of formula (I). It also relates to a pharmaceutical composition comprising at least one compound of formula (I) and at least one pharmaceutically acceptable support. Finally, it relates to the use of such a compound as a medicine, preferably in the treatment of a nervous and/or respiratory failure due to intoxication with at least one organophosphorous nerve agent; in the treatment of neurological diseases such as Alzheimer’s disease; and/or in the treatment of cancer.

公开(公告)号：US11633424B2

公开(公告)日：2023-04-25

申请号：US17254145

申请日：2019-06-19

Applicant: The University of North Carolina at Chapel Hill

Inventor： Jian Liu ,  Jine Li ,  Guowei Su ,  Rafal Pawlinski ,  Erica Sparkenbaugh

IPC: A61K31/737 ,  A61P39/02

Abstract: Chondroitin sulfate compounds comprising chondroitin sulfate backbone 19 mer, CS-A 19 mer, CS-C 19 mer, CS-E 19 mer, C8 backbone 13 mer, C8-A 13 mer, CS-C 13 mer, CS-E 13 mer and/or combinations thereof are provided. Methods of treating histone toxicity in a subject are provided, the methods including administering to a subject a chondroitin sulfate compound to treat the histone toxicity in the subject. Pharmaceutical compositions for use in treating histone toxicity and/or sepsis are provided. Methods of treating sepsis in a subject are provided, the methods including administering to a subject a chondroitin sulfate compound to treat the sepsis in the subject.

公开(公告)号：US11622975B2

公开(公告)日：2023-04-11

申请号：US16512897

申请日：2019-07-16

Applicant: The United States of America, as represented by the Secretary of Agriculture

Inventor： Yanping Chen ,  Matthew C. Heerman ,  Steven C. Cook ,  Jay D. Evans

IPC: A61K31/724 ,  A01K53/00 ,  A61P39/02 ,  A61K9/00 ,  A61K31/355 ,  A61K47/69 ,  A61P31/04

Abstract: Compositions comprising a mixture of at least one cyclodextrin, a carrier, and optionally one or more vitamins and/or nutrients to improve at least one health factor of a beehive is disclosed. Methods of improving beehive health and apparatuses including such compositions are also disclosed.

公开(公告)号：US20230074200A1

公开(公告)日：2023-03-09

申请号：US17819111

申请日：2022-08-11

Applicant: Catalyst Pharmaceuticals, Inc.

Inventor： Patrick MCNUTT

IPC: A61K31/44 ,  A61P39/02

Abstract: The present disclosure relates to a method of treating botulism poisoning comprising administering to a subject in need thereof, an effective amount of 3, 4-diaminopyridine, or a pharmaceutically acceptable salt thereof, via continuous infusion, single bolus injection, or orally.

公开(公告)号：US20220372565A1

公开(公告)日：2022-11-24

申请号：US17805657

申请日：2022-06-06

Applicant: Touchlight IP Limited

Inventor： Vanessa Hill

IPC: C12Q1/6853 ,  C12N15/11 ,  A61K39/00 ,  A61K48/00 ,  C12N9/02 ,  C12Q1/6844 ,  A61P37/08 ,  A61P39/02 ,  A61P37/04 ,  A61P35/00 ,  A61P33/00 ,  A61P37/00

Abstract: An in vitro process for the production of closed linear deoxyribonucleic acid (DNA) comprises (a) contacting a DNA template comprising at least one protelomerase target sequence with at least one DNA polymerase in the presence of one or more primers under conditions promoting amplification of the template; and (b) contacting amplified DNA produced in (a) with at least one protelomerase under conditions promoting production of closed linear DNA. A kit provides components necessary in the process.