发明申请
US20050020686A1 Remedies for diseases with bone mass loss having ep4 agonist as the active ingredient
失效
用ep4激动剂作为活性成分治疗骨质量下降的疾病
- 专利标题： Remedies for diseases with bone mass loss having ep4 agonist as the active ingredient
- 专利标题（中）： 用ep4激动剂作为活性成分治疗骨质量下降的疾病
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申请号： US10484500申请日： 2002-07-22
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公开(公告)号： US20050020686A1公开(公告)日： 2005-01-27
- 发明人: Toru Maruyama , Kaoru Kobayashi , Tohru Kambe , Takayuki Maruyama , Hideyuki Yoshida , Akio Nishiura , Nobutaka Abe
- 申请人： Toru Maruyama , Kaoru Kobayashi , Tohru Kambe , Takayuki Maruyama , Hideyuki Yoshida , Akio Nishiura , Nobutaka Abe
- 优先权： JP2001-222148 20010723; JP2001-239895 20010807; JP2002-56449 20020301
- 国际申请： PCT/JP02/07385 WO 20020722
- 主分类号： A61K45/00
- IPC分类号： A61K45/00 ; A61K31/559 ; A61P19/08 ; A61P19/10 ; C07C405/00 ; A61K31/557
摘要：
A pharmaceutical composition for topical administration for prevention and/or treatment of diseases associated with decrease in bone mass comprising an EP4 agonist as an active ingredient. An EP4 agonist, in which includes a compound possessing prostaglandin skeleton as a representative, possesses promoting action on bone formation, so it is useful for prevention and/or treatment of diseases associated with decrease in bone mass (bone diseases such as primary osteoporosis, secondary osteoporosis, bone metastasis of cancer, hypercalcemia, Paget's disease, bone loss and bone necrosis, postoperative osteogenesis, alternative therapy for bone grafting).
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