公开(公告)号：US20130310438A1

公开(公告)日：2013-11-21

申请号：US13982052

申请日：2012-01-26

申请人： Toru Maruyama ,  Tohru Kambe ,  Shinsaku Yamane ,  Satoshi Nakayama

发明人： Toru Maruyama ,  Tohru Kambe ,  Shinsaku Yamane ,  Satoshi Nakayama

IPC分类号： C07D335/04

CPC分类号： C07D335/04 ,  C07F7/1804

摘要： Provided is a compound which has strong intraocular pressure lowering action and has no side effect on eyes such as ocular stimulating property, humor protein rise etc.Since a compound represented by the formula (I): (wherein definition of each group is as described in the specification), or a salt thereof, a solvate thereof, or a prodrug thereof has strong intraocular pressure lowering activity and, further, has no side effect on eyes such as ocular stimulating property (hyperemia, corneal clouding etc.), aqueous humor protein rise etc., it has high safety, and can be an excellent agent for preventing and/or treating glaucoma etc.

摘要翻译： 本发明提供一种具有强烈的眼内降低作用，对眼睛无刺激性，幽默蛋白质上升等副作用的化合物。由式（I）表示的化合物：（其中，各组的定义如 说明书）或其盐，其溶剂合物或其前药具有强烈的眼内压降低活性，并且对眼睛没有副作用，例如眼刺激性（充血，角膜混浊等），房水蛋白 上升等，安全性高，可以作为预防和/或治疗青光眼等的优异剂。

公开(公告)号：US20130036865A1

公开(公告)日：2013-02-14

申请号：US13641880

申请日：2011-04-20

申请人： Tomohiro Sato ,  Yoshimasa Hirai ,  Toru Maruyama ,  Takeshi Kobayashi

发明人： Tomohiro Sato ,  Yoshimasa Hirai ,  Toru Maruyama ,  Takeshi Kobayashi

IPC分类号： C22C9/00

CPC分类号： C22C1/0425 ,  B22F1/0003 ,  B22F7/02 ,  B22F7/08 ,  B22F9/082 ,  C22C9/00 ,  C22C9/02 ,  C22C32/0089 ,  F16C2204/12 ,  F16C2220/20

摘要： A copper alloy having excellent sliding performance is produced without relying on lead or molybdenum. The copper alloy contains a sintered Cu5FeS4 material produced by sintering a raw material powder that comprises Cu, Fe and S and is produced by a gas atomizing method.

摘要翻译： 不依赖于铅或钼制造具有优异滑动性能的铜合金。 铜合金含有通过烧结包含Cu，Fe和S的原料粉末并通过气体雾化法制造的烧结的Cu 5 FeS 4材料。

公开(公告)号：US20110159782A1

公开(公告)日：2011-06-30

申请号：US12974123

申请日：2010-12-21

申请人： Tadakazu SONE ,  Yasuyuki MOTOSHIMA ,  Toru MARUYAMA ,  Katsutoshi ONO ,  Yoichi SHIOKAWA

发明人： Tadakazu SONE ,  Yasuyuki MOTOSHIMA ,  Toru MARUYAMA ,  Katsutoshi ONO ,  Yoichi SHIOKAWA

IPC分类号： B24B51/00

CPC分类号： B24B37/015 ,  B24B37/042 ,  B24B37/10 ,  B24B37/34 ,  B24B55/02

摘要： An apparatus for polishing a substrate is provided. The apparatus includes: a rotatable polishing table supporting a polishing pad; a substrate holder configured to hold a substrate and press the substrate against a polishing surface of the polishing pad on the rotating polishing table so as to polish the substrate; a pad-temperature detector configured to measure a temperature of the polishing surface of the polishing pad; a pad-temperature regulator configured to contact the polishing surface to regulate the temperature of the polishing surface; and a temperature controller configured to control the temperature of the polishing surface by controlling the pad-temperature regulator based on information on the temperature of the polishing surface detected by the pad-temperature detector.

摘要翻译： 提供了一种用于抛光衬底的设备。 该装置包括：支撑抛光垫的可旋转抛光台; 衬底保持器，其构造成保持衬底并将衬底压靠在旋转的抛光台上的抛光垫的抛光表面上以抛光衬底; 焊盘温度检测器，被配置为测量抛光垫的抛光表面的温度; 衬垫温度调节器，被配置为接触抛光表面以调节抛光表面的温度; 以及温度控制器，其被配置为通过基于由所述焊盘温度检测器检测到的关于所述抛光表面的温度的信息来控制所述焊盘温度调节器来控制所述抛光表面的温度。

公开(公告)号：US20080033033A1

公开(公告)日：2008-02-07

申请号：US11749531

申请日：2007-05-16

申请人： Tohru Kambe ,  Toru Maruyama ,  Kaoru Kobayashi ,  Kousuke Tani ,  Yoshihiko Nakai ,  Toshihiko Nagase ,  Takayuki Maruyama ,  Kiyoto Sakata ,  Hideyuki Yoshida ,  Shinsei Fujimura ,  Akio Nishiura ,  Nobutaka Abe

发明人： Tohru Kambe ,  Toru Maruyama ,  Kaoru Kobayashi ,  Kousuke Tani ,  Yoshihiko Nakai ,  Toshihiko Nagase ,  Takayuki Maruyama ,  Kiyoto Sakata ,  Hideyuki Yoshida ,  Shinsei Fujimura ,  Akio Nishiura ,  Nobutaka Abe

IPC分类号： A61K31/41 ,  A61K31/4015 ,  C07D207/18 ,  C07D257/04

CPC分类号： C07D417/12 ,  C07D417/14

摘要： The pharmaceutical composition comprising the compound of the invention having 8-azaprostaglandin skeleton represented by formula (I) (wherein, all the symbols have the same meanings as that of the specification.) a salt thereof, a solvate thereof or a cyclodextrin clathrate thereof, or a prodrug thereof and them as active ingredient have EP4 agonistic action and thus are considered useful for the prevention and/or treatment of immunological diseases, asthma, neuronal cell death, arthritis, lung failure, pulmonary fibrosis, pulmonary emphysema, bronchitis, chronic obstructive pulmonary disease, liver damage, acute hepatitis, nephritis, renal insufficiency, hypertension, myocardial ischemia, systemic inflammatory response syndrome, sepsis, hemophagous syndrome, macrophage activation syndrome, Still's disease, Kawasaki disease, burn, systemic granulomatosis, ulcerative colitis, Crohn's disease, hypercytokinemia at dialysis, multiple organ failure, shock and glaucoma, etc. Furthermore, the compounds also have an action of accelerating bone formation, so it is expected to be useful for the prevention and/or treatment of diseases associated with loss in bone mass, for example, primary osteoporosis, secondary osteoporosis, bone metastasis of cancer, hypercalcemia, Paget's disease, bone loss, osteonecrosis, bone formation after bone operation, alternative treatment for bone grafting.

摘要翻译： 包含本发明化合物的盐，其盐，其溶剂合物或环糊精包合物，其具有由式（I）表示的8-氮杂前列腺素骨架（其中所有符号具有与说明书相同的含义） 或其前药，并且它们作为活性成分具有EP 4激动作用，因此被认为可用于预防和/或治疗免疫疾病，哮喘，神经元细胞死亡，关节炎，肺衰竭，肺纤维化 ，肺气肿，支气管炎，慢性阻塞性肺疾病，肝损伤，急性肝炎，肾炎，肾功能不全，高血压，心肌缺血，全身炎症反应综合征，败血症，血液综合征，巨噬细胞活化综合征，静脉炎，川崎病，烧伤，系统性 肉芽肿病，溃疡性结肠炎，克罗恩病，透析中的高细胞因子血症，多器官功能衰竭，休克和青光眼等。 此外，化合物还具有促进骨形成的作用，因此预期可用于预防和/或治疗与骨量丧失相关的疾病，例如原发性骨质疏松症，继发性骨质疏松症，癌症的骨转移， 高钙血症，佩吉特氏病，骨丢失，骨坏死，骨手术后的骨形成，骨移植的替代治疗。

公开(公告)号：US20050020686A1

公开(公告)日：2005-01-27

申请号：US10484500

申请日：2002-07-22

申请人： Toru Maruyama ,  Kaoru Kobayashi ,  Tohru Kambe ,  Takayuki Maruyama ,  Hideyuki Yoshida ,  Akio Nishiura ,  Nobutaka Abe

发明人： Toru Maruyama ,  Kaoru Kobayashi ,  Tohru Kambe ,  Takayuki Maruyama ,  Hideyuki Yoshida ,  Akio Nishiura ,  Nobutaka Abe

IPC分类号： A61K45/00 ,  A61K31/559 ,  A61P19/08 ,  A61P19/10 ,  C07C405/00 ,  A61K31/557

CPC分类号： C07C405/0033 ,  A61K9/0019 ,  A61K9/1647 ,  A61K9/19 ,  A61K9/2054 ,  A61K31/4015 ,  A61K31/41 ,  A61K31/5575 ,  A61K31/559

摘要： A pharmaceutical composition for topical administration for prevention and/or treatment of diseases associated with decrease in bone mass comprising an EP4 agonist as an active ingredient. An EP4 agonist, in which includes a compound possessing prostaglandin skeleton as a representative, possesses promoting action on bone formation, so it is useful for prevention and/or treatment of diseases associated with decrease in bone mass (bone diseases such as primary osteoporosis, secondary osteoporosis, bone metastasis of cancer, hypercalcemia, Paget's disease, bone loss and bone necrosis, postoperative osteogenesis, alternative therapy for bone grafting).

摘要翻译： 用于预防和/或治疗与包含EP4激动剂作为活性成分的骨量减少相关的疾病的局部施用的药物组合物。 包含具有前列腺素骨架的化合物作为代表的EP4激动剂具有促进骨形成的作用，因此可用于预防和/或治疗与骨质量减少有关的疾病（骨疾病如原发性骨质疏松症，继发性骨质疏松症 骨质疏松症，癌症的骨转移，高钙血症，佩吉特氏病，骨丢失和骨坏死，术后成骨，骨移植的替代疗法）。

公开(公告)号：US5779505A

公开(公告)日：1998-07-14

申请号：US489470

申请日：1995-06-12

申请人： Masanori Yagi ,  Masahiro Shiga ,  Toru Maruyama

发明人： Masanori Yagi ,  Masahiro Shiga ,  Toru Maruyama

IPC分类号： H01R13/04 ,  H01R9/16 ,  H01R43/16 ,  H01R43/24 ,  H01R13/405

CPC分类号： H01R12/716 ,  H01R43/24 ,  H01R43/16 ,  Y10T29/4922

摘要： An improved electrical connector has terminals with tapered mold engaging ends formed to be complimentary in shape to notches made in a mold component in order to retain the pitch of the terminal ends during injection molding of a connector housing thereabout.

摘要翻译： 改进的电连接器具有端部，其端部具有锥形模具接合端，其形状与形成于模具部件中的凹口互补，以便在其周围的连接器壳体注塑期间保持端子的节距。

公开(公告)号：US09475167B2

公开(公告)日：2016-10-25

申请号：US13397908

申请日：2012-02-16

申请人： Toru Maruyama ,  Tadakazu Sone ,  Yasuyuki Motoshima

发明人： Toru Maruyama ,  Tadakazu Sone ,  Yasuyuki Motoshima

IPC分类号： B24B37/015 ,  B24B37/04

CPC分类号： B24B37/04 ,  B24B37/015

摘要： A substrate polishing apparatus includes: a polishing table supporting a polishing pad; a top ring configured to press the substrate against the polishing pad; and a pad temperature regulator configured to regulate a surface temperature of the polishing pad. The pad temperature regulator includes a pad contact element and a liquid supply system configured to supply a temperature-controlled liquid to the pad contact element. The pad contact element has a space therein and a partition that divide the space into a first liquid passage and a second liquid passage that are connected in series. At least one baffle substantially perpendicular to a radial direction of the polishing table is provided in each of the first liquid passage and the second liquid passage.

摘要翻译： 衬底抛光装置包括：支撑抛光垫的抛光台; 顶环，构造成将衬底压靠在抛光垫上; 以及衬垫温度调节器，其构造成调节抛光垫的表面温度。 焊盘温度调节器包括焊盘接触元件和液体供应系统，该液体供应系统被配置为将温度控制的液体供应到焊盘接触元件。 垫接触元件在其中具有空间和将空间分成串联连接的第一液体通道和第二液体通道的隔板。 在第一液体通道和第二液体通道的每一个中设置至少一个基本上垂直于抛光台的径向的挡板。

公开(公告)号：US09150537B2

公开(公告)日：2015-10-06

申请号：US13982052

申请日：2012-01-26

申请人： Toru Maruyama ,  Tohru Kambe ,  Shinsaku Yamane ,  Satoshi Nakayama

发明人： Toru Maruyama ,  Tohru Kambe ,  Shinsaku Yamane ,  Satoshi Nakayama

IPC分类号： C07D335/04 ,  C07F7/18

CPC分类号： C07D335/04 ,  C07F7/1804

摘要： Provided is a compound which has strong intraocular pressure lowering action and has no side effect on eyes such as ocular stimulating property, humor protein rise etc.Since a compound represented by the formula (I): (wherein definition of each group is as described in the specification), or a salt thereof, a solvate thereof, or a prodrug thereof has strong intraocular pressure lowering activity and, further, has no side effect on eyes such as ocular stimulating property (hyperemia, corneal clouding etc.), aqueous humor protein rise etc., it has high safety, and can be an excellent agent for preventing and/or treating glaucoma etc.

摘要翻译： 本发明提供一种具有强烈的眼内降低作用，对眼睛无刺激性，幽默蛋白质上升等副作用的化合物。由式（I）表示的化合物：（其中，各组的定义如 说明书）或其盐，其溶剂合物或其前药具有强烈的眼内压降低活性，并且对眼睛没有副作用，例如眼刺激性（充血，角膜混浊等），房水蛋白 上升等，安全性高，可以作为预防和/或治疗青光眼等的优异剂。

公开(公告)号：US08845391B2

公开(公告)日：2014-09-30

申请号：US12974123

申请日：2010-12-21

申请人： Tadakazu Sone ,  Yasuyuki Motoshima ,  Toru Maruyama ,  Katsutoshi Ono ,  Yoichi Shiokawa

发明人： Tadakazu Sone ,  Yasuyuki Motoshima ,  Toru Maruyama ,  Katsutoshi Ono ,  Yoichi Shiokawa

IPC分类号： B24B1/00 ,  B24B55/02 ,  B24B37/015 ,  B24B37/34 ,  B24B37/10

CPC分类号： B24B37/015 ,  B24B37/042 ,  B24B37/10 ,  B24B37/34 ,  B24B55/02

摘要： An apparatus for polishing a substrate includes a rotatable polishing table supporting a polishing pad, a substrate holder configured to hold the substrate and press the substrate against a polishing surface of the polishing pad on the rotating polishing table so as to polish the substrate, and a pad-temperature detector configured to measure a temperature of the polishing surface of the polishing pad. The apparatus also includes a pad-temperature regulator configured to contact the polishing surface to regulate the temperature of the polishing surface, and a temperature controller configured to control the temperature of the polishing surface by controlling the pad-temperature regulator based on information on the temperature of the polishing surface detected by the pad-temperature detector.

摘要翻译： 用于抛光基板的装置包括：支撑抛光垫的可旋转的抛光台;衬底保持器，其构造成保持基板，并将基板压靠在旋转的抛光台上的抛光垫的抛光表面上，以便抛光基板;以及 衬垫温度检测器，被配置为测量抛光垫的抛光表面的温度。 该装置还包括：衬垫温度调节器，其被配置为接触抛光表面以调节抛光表面的温度;以及温度控制器，其被配置为通过基于关于温度的信息控制焊盘温度调节器来控制抛光表面的温度 由焊盘温度检测器检测到的抛光表面。

公开(公告)号：US20120240537A1

公开(公告)日：2012-09-27

申请号：US13426791

申请日：2012-03-22

申请人： Toru MARUYAMA

发明人： Toru MARUYAMA

IPC分类号： B01D46/42

CPC分类号： F25B43/02

摘要： A disclosed oil separator provided in a flow path of a refrigerant gas flowing from a compressor to a refrigerator including a filter configured to form an internal space by including a filter material filtering out oil from the refrigerant gas, an upper lid bonded to an upper portion of the filter material, and a lower lid bonded to a lower portion of the filter material; a body accommodating the filter; a gas inlet pipe introducing the refrigerant gas into the internal space; and a gas outlet pipe ejecting the refrigerant gas from which the oil is filtered out by the filter from an upper portion of the body, wherein a lower end of the gas inlet pipe is opened to the internal space at a position higher than the lower lid and lower than a substantial center between the upper lid and the lower lid.

摘要翻译： 一种公开的油分离器，其设置在从压缩机流向冷冻机的制冷剂气体的流路中，所述制冷剂气体包括通过包括从制冷剂气体中除去油的过滤材料构成而形成内部空间的过滤器，上盖接合到上部 的过滤材料的下部和与过滤材料的下部接合的下盖; 容纳过滤器的主体; 将制冷剂气体导入内部空间的气体导入管; 以及气体出口管，其从所述主体的上部喷射通过所述过滤器从所述过滤器排出的所述制冷剂气体，其中，所述气体导入管的下端在高于所述下盖的位置向所述内部空间开放 并且低于上盖和下盖之间的实质中心。