发明申请
- 专利标题： MATRIX METALLOPROTEINASE INHIBITORS
- 专利标题（中）： 基质金属蛋白酶抑制剂
-
申请号： US09783248申请日： 2001-02-14
-
公开(公告)号： US20050025702A1公开(公告)日： 2005-02-03
- 发明人: Carl Decicco , David Nelson , John Barrett , Alan Carpenter , Jingwu Duan , Milind Rajopadhye
- 申请人： Carl Decicco , David Nelson , John Barrett , Alan Carpenter , Jingwu Duan , Milind Rajopadhye
- 主分类号： A61K49/00
- IPC分类号： A61K49/00 ; A61K49/14 ; A61K51/08 ; C07D207/26 ; C07D213/82 ; C07D267/00 ; C07D401/12 ; C07D401/14 ; C07D413/12 ; C07F9/6527 ; A61K51/00
摘要：
Thus the present invention describes novel compounds comprising: 1-10 targeting moieties; a chelator (Ch); and 0-1 linking groups (Ln) between the targeting moiety and chelator; wherein the targeting moiety is a matrix metalloproteinase inhibitor; and wherein the chelator is capable of conjugating to a cytotoxic radioisotope. The present invention also provides novel compositions of the compounds of the invention, kits, and their uses in treatment of diseases associated with MMPs.
公开/授权文献
- US06989139B2 Matrix metalloproteinase inhibitors 公开/授权日：2006-01-24
信息查询
