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    PALLADIUM ION ADSORBENT AND METHODS FOR SEPARATING AND RECOVERING PALLADIUM USING IT
    4.
    发明申请
    PALLADIUM ION ADSORBENT AND METHODS FOR SEPARATING AND RECOVERING PALLADIUM USING IT 审中-公开
    阳离子吸附剂和使用其分离和回收钯的方法

    公开(公告)号：US20120164039A1

    公开(公告)日：2012-06-28

    申请号：US13391213

    申请日：2010-08-20

    申请人： Yukinori Sudo

    发明人： Yukinori Sudo

    IPC分类号： C01G55/00 ,  B01J20/22 ,  C07D267/00

    CPC分类号： C22B11/042 ,  B01J20/28047 ,  B01J20/3204 ,  B01J20/321 ,  B01J20/3212 ,  B01J20/3242 ,  B01J20/3255 ,  B01J20/3425 ,  B01J20/3475 ,  C07D285/00 ,  C22B3/24 ,  C22B7/006 ,  Y02P10/214 ,  Y02P10/234

    摘要： To provide a solid-liquid palladium ion adsorbent which has both extraction performance and selectivity of a liquid-liquid palladium extracting agent in a conventional solvent extraction method and which does not require use of an organic solvent, and methods for selectively separating and recovering palladium, using it.Palladium is selectively separated and recovered by using a palladium ion adsorbent comprising an amide-containing cyclic sulfide compound represented by the following formula (1) or (2), or a palladium ion adsorbent having the amide-containing cyclic sulfide compound represented by the following formula (1) or (2) fixed on a carrier: wherein R is each independently a hydrogen atom, a methyl group, an ethyl group, a C3-30 linear or branched chain hydrocarbon group, a C3-10 alicyclic hydrocarbon group or a C6-14 aromatic hydrocarbon group, m is an integer of 1 or 2, n is each independently an integer of from 1 to 12, and L is each independently a methylene group, an ethylene group, a C3-8 alkylene group or a C6-14 arylene group; wherein R is each independently a hydrogen atom, a methyl group, an ethyl group, a C3-30 linear or branched chain hydrocarbon group, a C3-10 alicyclic hydrocarbon group or a C6-14 aromatic hydrocarbon group, n is each independently an integer of from 1 to 4, and L is each independently a methylene group, an ethylene group, a C3-8 alkylene group or a C6-14 arylene group.

    摘要翻译： 为了提供一种在常规溶剂萃取方法中具有液 - 液钯提取剂的萃取性能和选择性，不需要使用有机溶剂的固液钯离子吸附剂，以及选择性分离和回收钯的方法， 使用它。 通过使用包含由下式（1）或（2）表示的含酰胺的环状硫化合物的钯离子吸附剂或具有由下述式（1）或（2）表示的含酰胺的环状硫化合物的钯离子吸附剂，选择性地分离和回收钯 式（1）或（2）固定在载体上：其中R各自独立地为氢原子，甲基，乙基，C 3-30直链或支链烃基，C 3-10脂环族烃基或 C 6-14芳族烃基，m为1或2的整数，n各自独立地为1〜12的整数，L各自独立地为亚甲基，亚乙基，C 3-8亚烷基或C 6 -14亚芳基; 其中R各自独立地为氢原子，甲基，乙基，C 3-30直链或支链烃基，C 3-10脂环族烃基或C 6-14芳族烃基，n各自独立地为整数 为1至4，L各自独立地为亚甲基，亚乙基，C 3-8亚烷基或C 6-14亚芳基。

    SYNTHETIC MACROCYCLIC COMPOUNDS AND METHODS FOR TREATING CANCER
    5.
    发明申请
    SYNTHETIC MACROCYCLIC COMPOUNDS AND METHODS FOR TREATING CANCER 审中-公开
    合成大环化合物和治疗癌症的方法

    公开(公告)号：US20120128657A1

    公开(公告)日：2012-05-24

    申请号：US12526477

    申请日：2008-02-07

    申请人： Carole A. Bewley ,  Belhu B. Metaferia ,  Xin-Yu Huang

    发明人： Carole A. Bewley ,  Belhu B. Metaferia ,  Xin-Yu Huang

    IPC分类号： A61K31/395 ,  A61K38/43 ,  A61K39/395 ,  A61K31/704 ,  A61K33/24 ,  A61K31/422 ,  A61K31/437 ,  A61K31/519 ,  A61K31/57 ,  A61K38/50 ,  A61P35/00 ,  A61P35/02 ,  A61P35/04 ,  A61P27/02 ,  A61P9/10 ,  A61P37/06 ,  A61P1/00 ,  A61P29/00 ,  A61P7/06 ,  C07D267/00

    CPC分类号： C07D267/00

    摘要： Disclosed herein are macrocyclic compounds that are effective to inhibit cell migration. In one embodiment, the compounds have the structure: or any pharmaceutically acceptable salt or solvate thereof, wherein: m is 0 or 1; R1, R2 and R3 independently are H, aralkyl, acyl, lower alkyl or silyl; X is —C(O)N(R4)— or —C(S)N(R4)—; —C(O)—; —C(S)—; Y is —OC(O)—; —OC(O)N(R5)—; —N(R5)C(O)—; or —OC(O)O—; G comprises a saturated or unsaturated aliphatic chain having from 2 to about 10 atoms in the chain, the chain optionally including 1, 2, or 3 heteroatoms; the chain optionally being substituted with 1, 2 or 3 substituents independently selected from lower alkyl, —OR6, epoxy, aziridinyl, cyclopropyl, —NR7R8 and halo; R4, R5, R6, R7 and R8 independently are selected from H, lower alkyl and acyl. Also disclosed are methods for making and using compounds as well as pharmaceutical compositions including one or more of the disclosed macrocycles.

    摘要翻译： 本文公开了有效抑制细胞迁移的大环化合物。 在一个实施方案中，化合物具有以下结构：或其任何药学上可接受的盐或溶剂化物，其中：m为0或1; R1，R2和R3独立地为H，芳烷基，酰基，低级烷基或甲硅烷基; X是-C（O）N（R4） - 或-C（S）N（R4） - ; -C（O） - ; -C（S） - ; Y为-OC（O） - ; -OC（O）N（R5） - ; -N（R 5）C（O） - ; 或-OC（O）O-; G包含在链中具有2至约10个原子的饱和或不饱和脂族链，该链任选地包括1,2或3个杂原子; 该链任选被1,2或3个独立地选自低级烷基，-OR 6，环氧基，氮丙啶基，环丙基，-NR 7 R 8和卤素的取代基取代; R4，R5，R6，R7和R8独立地选自H，低级烷基和酰基。 还公开了制备和使用化合物的方法以及包含一种或多种所公开的大环化合物的药物组合物。

    Macrocyclic beta-secretase inhibitors for the treatment of alzheimer's disease
    9.
    发明申请
    Macrocyclic beta-secretase inhibitors for the treatment of alzheimer's disease 有权
    用于治疗阿尔茨海默氏病的大环β-分泌酶抑制剂

    公开(公告)号：US20060058278A1

    公开(公告)日：2006-03-16

    申请号：US10541476

    申请日：2004-01-02

    申请人： Craig Coburn ,  Shawn Stachel ,  Joseph Vacca

    发明人： Craig Coburn ,  Shawn Stachel ,  Joseph Vacca

    IPC分类号： C07D267/00

    CPC分类号： C07D273/02

    摘要： The present invention is directed to compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment or prevention of diseases in which the beta-secretase enzyme in involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the beta-secretase enzyme is involved.

    摘要翻译： 本发明涉及式（I）化合物，