发明申请
US20050026811A1 Rage antagonists as agents to reverse amyloidosis and diseases associated therewith
审中-公开
愤怒的拮抗剂作为逆转淀粉样变性的药物和与之相关的疾病
- 专利标题: Rage antagonists as agents to reverse amyloidosis and diseases associated therewith
- 专利标题(中): 愤怒的拮抗剂作为逆转淀粉样变性的药物和与之相关的疾病
-
申请号: US10850238申请日: 2004-05-20
-
公开(公告)号: US20050026811A1公开(公告)日: 2005-02-03
- 发明人: Adnan Mjalli , Robert Andrews , Jane Shen , Robert Rothlein
- 申请人: Adnan Mjalli , Robert Andrews , Jane Shen , Robert Rothlein
- 主分类号: A61K31/4164
- IPC分类号: A61K31/4164 ; A61K31/4184 ; A61K31/425 ; A61P25/28 ; A61K38/00
摘要:
Disclosed are RAGE antagonist compounds that have the ability to reverse pre-existing amyloidosis. Treatment with the RAGE antagonist compounds described herein may be used to reduce plaque size and improve cognition for subjects in the later stages of Alzheimer's disease. Additionally, the RAGE antagonists described herein may be used to reduce the onset of plaque formation and thereby prevent loss of cognition and other symptoms associated with Alzheimer's Disease and other diseases of amyloid deposition.