发明申请
- 专利标题： Uses of opg to modulate immune responses
- 专利标题（中）： opg用于调节免疫反应
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申请号： US10129595申请日： 2002-02-06
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公开(公告)号： US20050031583A1公开(公告)日： 2005-02-10
- 发明人: Iqbal Grewal
- 申请人： Iqbal Grewal
- 国际申请： PCT/US02/01238 WO 20020206
- 主分类号： C12N15/09
- IPC分类号： C12N15/09 ; A61K38/00 ; A61K39/395 ; A61K48/00 ; A61P1/04 ; A61P3/10 ; A61P17/06 ; A61P19/00 ; A61P19/02 ; A61P29/00 ; A61P31/00 ; A61P37/00 ; A61P37/02 ; A61P37/06 ; A61P37/08 ; C07K14/705 ; C12N5/06 ; C12N5/08 ; A61K38/20
摘要：
Methods of stimulating or inhibiting activity of monocytes using OPG ligand, or other agonists or antagonists, are provided. Methods of treating pathological conditions, particularly immune related conditions, using such OPG ligand, agonists or antagonists are further provided. Agonists and antagonists contemplated for use in the invention include anti-RANK receptor antibodies, anti-OPG ligand antibodies, anti-OPG receptor antibodies, RANK receptor immunoadhesins, and OPG receptor immunoadhesins.
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