发明申请
- 专利标题： Polynucleotides encoding novel adiponectin receptor variants
- 专利标题（中）： 编码新型脂联素受体变体的多核苷酸
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申请号： US10874923申请日： 2004-06-23
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公开(公告)号： US20050032166A1公开(公告)日： 2005-02-10
- 发明人: Jian Chen , Shujian Wu , Ning Lee
- 申请人： Jian Chen , Shujian Wu , Ning Lee
- 主分类号： C07H21/04
- IPC分类号： C07H21/04 ; C07K14/705 ; C07K14/72 ; C12N20060101 ; C12P21/04
摘要：
The present invention provides novel polynucleotides encoding human AdipoR2v1 polypeptides, mouse AdipoR2v1 polypeptides, human AdipoR3 polypeptides, human AdipoR2v2 polypeptides, human AdipoR3v1 polypeptides, rat AdipoR1 polypeptides, rat AdipoR2 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel human AdipoR2v1 polypeptides, mouse AdipoR2v1 polypeptides, human AdipoR3 polypeptides, human AdipoR2v2 polypeptides, human AdipoR3v1 polypeptides, rat AdipoR1 polypeptides, rat AdipoR2 polypeptides, to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.