发明申请
US20050032175A1 High affinity fusion proteins and therapeutic and diagnostic methods for use
审中-公开
高亲和力融合蛋白和治疗和诊断方法使用
- 专利标题： High affinity fusion proteins and therapeutic and diagnostic methods for use
- 专利标题（中）： 高亲和力融合蛋白和治疗和诊断方法使用
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申请号： US10879994申请日： 2004-06-29
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公开(公告)号： US20050032175A1公开(公告)日： 2005-02-10
- 发明人: Neil Stahl , George Yancopoulos , Margaret Karow , Eric Smith
- 申请人： Neil Stahl , George Yancopoulos , Margaret Karow , Eric Smith
- 主分类号： C07K14/715
- IPC分类号： C07K14/715 ; C07K16/24 ; C07K16/46 ; C12N15/62 ; C12P21/04 ; C07H21/04 ; C07K16/40 ; C12N9/64
摘要：
High affinity fusion proteins capable of binding and inhibiting the activity of soluble, interacting proteins (“SIPs”) are described. In specific embodiments the fusion proteins are multimers, preferably dimers, of SIP-specific fusion polypeptides which comprise SIP binding domains derived from SIP targets and/or anti-SIP immunoglobulin domains, as well as multimerizing components.