Invention Application
- Patent Title: Phenacyl 2-hydroxy-3-diaminoalkanes
- Patent Title (中): 苯甲酰基2-羟基-3-二氨基烷烃
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Application No.: US10828582Application Date: 2004-04-21
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Publication No.: US20050054690A1Publication Date: 2005-03-10
- Inventor: Jose Aquino , Varghese John , John Tucker , Roy Hom , Shon Pulley , Ruth Tenbrink
- Applicant: Jose Aquino , Varghese John , John Tucker , Roy Hom , Shon Pulley , Ruth Tenbrink
- Main IPC: A61P25/00
- IPC: A61P25/00 ; A61P25/28 ; C07C233/40 ; C07C235/34 ; C07D209/20 ; C07D213/40 ; C07D215/42 ; C07D311/68 ; C07D335/06 ; C07D409/12 ; C07D413/12 ; A61K31/44 ; A61K31/137 ; A61K31/40
Abstract:
The present invention relates to compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are also useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
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