发明申请
- 专利标题： 6-Methoxy-2-naphthylacetic acid prodrugs
- 专利标题（中）： 6-甲氧基-2-萘基乙酸前药
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申请号： US10970571申请日： 2004-10-21
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公开(公告)号： US20050054735A1公开(公告)日： 2005-03-10
- 发明人: Nnochiri Ekwuribe , Tatyana Dyakonov
- 申请人： Nnochiri Ekwuribe , Tatyana Dyakonov
- 主分类号： A61P29/00
- IPC分类号： A61P29/00 ; A61K31/085 ; A61K31/16 ; A61K31/165 ; A61K31/167 ; A61K31/21 ; A61K31/216 ; A61K31/222 ; A61K31/235 ; A61K31/265 ; C07C43/23 ; A61K31/445 ; A61K31/075 ; A61K31/12
摘要：
The present invention provides therapeutically effective amounts of 6MNA prodrugs. The pharmaceutical composition comprises wherein R is H or COR′, wherein R′ is selected from the group consisting of C1 to C6 alkyl, (CH2)m O(CH2)n, (CH2)m(OC2H4)p O(CH2)n, (CH2)m(OC2H4)p, (OCH2H4)p ONO2 and (OCH2H4)p O(CH2)n wherein m is an integer from 2 to 4, and n and p are integers from 1 to 4. Alternatively, R is a therapeutic moiety.