发明申请
- 专利标题： Preparation of substituted butenolides via palladium-free etherification and amination of masked mucohalic acids
- 专利标题（中）： 通过无钯醚化和胺化掩蔽的粘酸盐制备取代丁烯酸酯
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申请号： US10942557申请日： 2004-09-16
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公开(公告)号： US20050059831A1公开(公告)日： 2005-03-17
- 发明人: Peter Blazecka , Ji Zhang
- 申请人： Peter Blazecka , Ji Zhang
- 主分类号： C07D307/60
- IPC分类号： C07D307/60 ; C07D307/66 ; C07D307/32
摘要：
Methods and materials for preparing 4-substituted-2-buten-4-olides are disclosed. The methods include reacting a masked mucohalic acid with a primary or secondary amine or with an arylol in the presence of a base. Unlike existing processes, the disclosed methods do not require the use of palladium, which make them well suited for preparing intermediates in drug syntheses.
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