发明申请
- 专利标题： Method for the preparation of escitalopram
- 专利标题（中）： 艾司西酞普兰的制备方法
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申请号： US10483824申请日： 2002-07-12
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公开(公告)号： US20050065207A1公开(公告)日： 2005-03-24
- 发明人: Michael Sommer , Ole Nielsen , Hans Petersen , Haleh Ahmadian , Henrik Pedersen , Peter Brosen , Fiona Geiser , James Lee , Geoffrey Cox , Olivier Dapremont , Christina Suteu , Sebastian Assenza , Shankar Hariharan , Usha Nair
- 申请人： Michael Sommer , Ole Nielsen , Hans Petersen , Haleh Ahmadian , Henrik Pedersen , Peter Brosen , Fiona Geiser , James Lee , Geoffrey Cox , Olivier Dapremont , Christina Suteu , Sebastian Assenza , Shankar Hariharan , Usha Nair
- 优先权： DKPA200101101 20010713; DKPA200101851 20011211; DKPA200101852 20011211
- 国际申请： PCT/DK02/00491 WO 20020712
- 主分类号： A61K31/343
- IPC分类号： A61K31/343 ; A61P25/24 ; C07B20060101 ; C07C215/32 ; C07C215/34 ; C07D20060101 ; C07D307/87
摘要：
A novel method is provided for the manufacture of escitalopram. The method comprises chromatographic separation of the enantiomers of citalopram or an intermediate in the production of citalopram using a chiral stationary phase such as Chiralpak™ or Chiralcel™ OD. Novel chiral intermediates for the synthesis of Escitalopram made by said method are also provided.
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