A method and apparatus are provided for broadband cancellation of interference signals. A signal transmitted on one communication path acts as an interference signal to a receiver on a second communication path in the system. In an embodiment, a signal transmitted from an antenna using one wireless standard, or protocol, acts as an interference signal for another antenna, co-located in the same system, using another wireless standard, or protocol, and operating in the same or nearby frequency bands. A time delay is applied to a signal sampled from the interference signal to provide substantially broadband cancellation of the interference signal. The sampled signal may be attenuated to match the amplitude of the interference signal on the second communication path. Coupling of the sampled signal from one communication path to the other communication path can provide an 180° phase shift to the sampled signal.