发明申请
US20050079184A1 Bispecific antibodies for inducing apoptosis of tumor and diseased cells
审中-公开
用于诱导肿瘤和患病细胞凋亡的双特异性抗体
- 专利标题： Bispecific antibodies for inducing apoptosis of tumor and diseased cells
- 专利标题（中）： 用于诱导肿瘤和患病细胞凋亡的双特异性抗体
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申请号： US10913509申请日： 2004-08-09
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公开(公告)号： US20050079184A1公开(公告)日： 2005-04-14
- 发明人: Chien Hsing-Chang , David Goldenberg , Hans Hansen , Eva Horak , Ivan Horak
- 申请人： Chien Hsing-Chang , David Goldenberg , Hans Hansen , Eva Horak , Ivan Horak
- 申请人地址： US NJ Morris Plains
- 专利权人： Immunomedics, Inc.
- 当前专利权人： Immunomedics, Inc.
- 当前专利权人地址： US NJ Morris Plains
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; C07K20060101 ; C07K16/28 ; C07K16/30 ; C07K16/46 ; G01N33/574
摘要：
The bispecific antibodies of the present invention are in the form of a heteroconjugate that inhibits growth and induces apoptosis of a diseased cell and that does not require the recruitment of effector cells. The heteroconjugate has at least two binding arms wherein each of the binding arms possesses a different specificity and need not have apoptotic activity when not conjugated to each other. Also provided are methods of treating and diagnosing a diseased cell using the bispecfic antibodies of the present invention.
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