发明申请
- 专利标题： Poly-pegylated protease inhibitors
- 专利标题（中）： 聚聚乙二醇化蛋白酶抑制剂
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申请号： US10931153申请日： 2004-08-30
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公开(公告)号： US20050089515A1公开(公告)日： 2005-04-28
- 发明人: Arthur Ley , Aaron Sato , Robert Ladner , Mark Stochl
- 申请人： Arthur Ley , Aaron Sato , Robert Ladner , Mark Stochl
- 专利权人： DYAX CORP.
- 当前专利权人： DYAX CORP.
- 主分类号： A61K38/43
- IPC分类号： A61K38/43 ; C07F20060101 ; C12N9/99 ; C12N15/09
摘要：
Disclosed are compounds that comprise: (i) a Kunitz domain polypeptide that comprises a Kunitz domain that binds to and inhibits a protease; and (ii) a plurality of polyethylene glycol moieties attached to the Kunitz domain polypeptide. Each accessible primary amine of the Kunitz domain polypeptide can be attached to one of the moieties. Also disclosed are related methods.