A multi-piece golf ball includes a core having a diameter of 30 to 40 mm, at least one intermediate layer including the outermost layer having a thickness of 0.5 to 2.0 mm, and a cover having a thickness of 1.0 to 3.0 mm. The core is made from a rubber composition mainly containing polybutadiene. The outermost layer is made from a non-ionomer based thermoplastic resin. The cover is made from a material obtained by dispersedly blending at least one kind of silicone powder selected from a silicone rubber powder, a silicon resin powder, and a composite powder thereof, in a main resin component containing an ionomer resin in an amount of 50% by weight or more. The core has a hardness corresponding to a deflection in a range of 3.5 to 6.5 mm under an applied load of 100 kg. The outermost layer of the at least one intermediate layer has a Dulometer D hardness in a range of 20 to 55, and the cover is harder than the outermost layer of the at least one intermediate layer and has a Dulometer D hardness in a range of 50 to 70. Dimples of the number of 300 to 550 pieces are formed in the surface of the golf ball in such a manner that a dimple total volume ratio VR, which is a ratio of the total of volumes of dimple spaces under the planes surrounded by edges of the dimples in the surface of the gold ball to the total volume of a virtual ball as a result of assumption that no dimple is formed in the surface of the golf ball, is in a range of 0.85% or less. The multi-piece golf ball is excellent in resilience, flight distance characteristic, and feel of hitting.