发明申请
- 专利标题： Dual NK1/NK3 receptor antagonists
- 专利标题（中）： 双NK1 / NK3受体拮抗剂
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申请号： US10884707申请日： 2004-07-02
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公开(公告)号： US20050090533A1公开(公告)日： 2005-04-28
- 发明人: Torsten Hoffmann , Andreas Koblet , Jens-Uwe Peters , Patrick Schnider , Andrew Sleight , Heinz Stadler
- 申请人： Torsten Hoffmann , Andreas Koblet , Jens-Uwe Peters , Patrick Schnider , Andrew Sleight , Heinz Stadler
- 优先权： EP03014513.0 20030703
- 主分类号： A61K31/44
- IPC分类号： A61K31/44 ; A61K31/4418 ; A61K31/4427 ; A61K31/4439 ; A61K31/444 ; A61K31/46 ; A61K31/496 ; A61K31/4995 ; A61K31/5377 ; A61K31/5386 ; A61K31/541 ; A61K31/547 ; A61K31/551 ; A61K31/554 ; C07D213/75 ; C07D401/04 ; C07D413/04 ; C07D417/04 ; C07D419/04 ; C07D451/04 ; C07D487/08 ; C07D491/10 ; C07D495/10 ; C07D497/10 ; C07D498/08 ; C07D513/08
摘要：
The present invention provides a method for the treatment of schizophrenia which comprises administering a compound of formula wherein the substituents are as described herein or a pharmaceutically active acid-addition salt thereof. In particular, the invention provides methods for treating both positive and negative symptoms of schizophrenia through dual inhibition of NK1 and NK3 receptors. The invention also provides novel compounds with formula I and methods for preparing compounds of the invention.
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