发明申请
- 专利标题： Benzannelated derivatives, their manufacture and use as pharmaceutical agents
- 专利标题（中）： 苄基化衍生物，其制造和用作药剂
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申请号： US10977651申请日： 2004-10-29
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公开(公告)号： US20050096336A1公开(公告)日： 2005-05-05
- 发明人: Jean Ackermann , Johannes Aebi , Alfred Binggeli , Uwe Grether , Georges Hirth , Bernd Kuhn , Hans-Peter Maerki , Markus Meyer , Peter Mohr , Matthew Wright
- 申请人： Jean Ackermann , Johannes Aebi , Alfred Binggeli , Uwe Grether , Georges Hirth , Bernd Kuhn , Hans-Peter Maerki , Markus Meyer , Peter Mohr , Matthew Wright
- 优先权： EP03104082.7 20031105
- 主分类号： C07D213/30
- IPC分类号： C07D213/30 ; C07D213/38 ; C07D239/26 ; A61K31/44 ; A61K31/192 ; A61K31/277 ; A61K31/343 ; A61K31/381
摘要：
There are presented compounds of the formula wherein R6 and R7 is R4 and R5 or R5 and R6 together with the carbon atoms to which they are attached, form a ring as defined in the description and X1, X2, Y1 to Y4, R1 to R13 and n are as specified in the description, and to all enantiomers and pharmaceutically acceptable salts and/or esters thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are modulated by PPARδ and/or PPARα agonists.
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