发明申请
US20050106683A1 Antibodies specific for sclerostin and methods for increasing bone mineralization
有权
针对硬皮蛋白的特异性抗体和增加骨矿化的方法
- 专利标题： Antibodies specific for sclerostin and methods for increasing bone mineralization
- 专利标题（中）： 针对硬皮蛋白的特异性抗体和增加骨矿化的方法
-
申请号： US10868497申请日： 2004-06-15
-
公开(公告)号： US20050106683A1公开(公告)日： 2005-05-19
- 发明人: David Winkler , Jiye Shi , John Latham
- 申请人： David Winkler , Jiye Shi , John Latham
- 申请人地址： GB Slough
- 专利权人： Celltech R & D Limited
- 当前专利权人： Celltech R & D Limited
- 当前专利权人地址： GB Slough
- 主分类号： A61P19/10
- IPC分类号： A61P19/10 ; C07K14/51 ; C07K16/18 ; C12P21/06 ; C12P21/04 ; C07K16/40 ; C07K16/28
摘要：
Compositions and methods relating to antibodies that specifically bind to TGF-beta binding proteins are provided. These methods and compositions relate to altering bone mineral density by interfering with the interaction between a TGF-beta binding protein sclerostin and a TGF-beta superfamily member, particularly a bone morphogenic protein. Increasing bone mineral density has uses in diseases and conditions in which low bone mineral density typifies the condition, such as osteopenia, osteoporosis, and bone fractures.
公开/授权文献
信息查询
