发明申请
- 专利标题： Antitumor agent containing lactic acid oligomer mixture
- 专利标题（中）： 含有乳酸低聚物混合物的抗肿瘤剂
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申请号： US10493051申请日： 2002-11-05
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公开(公告)号： US20050107464A1公开(公告)日： 2005-05-19
- 发明人: Yasukazu Nagato , Shigeo Takada , Chieko Murayama , Mikio Watanabe , Masahiro Murakami
- 申请人： Yasukazu Nagato , Shigeo Takada , Chieko Murayama , Mikio Watanabe , Masahiro Murakami
- 优先权： JP2001-340680 20021106
- 国际申请： PCT/JP02/11505 WO 20021105
- 主分类号： A61K31/22
- IPC分类号： A61K31/22 ; A61K31/225 ; A61K31/365 ; A61K31/765 ; A61P35/00 ; C07D323/00
摘要：
An object of the present invention is to provide a novel antitumor agent by evaluating the antitumor effect obtained by a mixture of polylactic acids which is produced by polymerizing lactides in the presence of certain amine compound. The present invention provides an antitumor agent which comprises a mixture of linear and cyclic lactic acid oligomers represented by the following formula (1) or (2): wherein m represents an integer of 1 to 30, and n represents an integer of 1 to 30, which is produced by polymerizing lactides in the presence of a compound represented by the following formula (3): Me—N(R1)(R2) (3) wherein Me represents an alkali metal, and each of R1 and R2 independently represents an aliphatic group or aromatic group.
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