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公开(公告)号：US20050107464A1
公开(公告)日：2005-05-19
申请号：US10493051
申请日：2002-11-05
IPC分类号： A61K31/22 , A61K31/225 , A61K31/365 , A61K31/765 , A61P35/00 , C07D323/00
CPC分类号： A61K31/765 , A61K31/22 , A61K31/225 , A61K31/365 , C07D323/00
摘要： An object of the present invention is to provide a novel antitumor agent by evaluating the antitumor effect obtained by a mixture of polylactic acids which is produced by polymerizing lactides in the presence of certain amine compound. The present invention provides an antitumor agent which comprises a mixture of linear and cyclic lactic acid oligomers represented by the following formula (1) or (2): wherein m represents an integer of 1 to 30, and n represents an integer of 1 to 30, which is produced by polymerizing lactides in the presence of a compound represented by the following formula (3): Me—N(R1)(R2) (3) wherein Me represents an alkali metal, and each of R1 and R2 independently represents an aliphatic group or aromatic group.
摘要翻译： 本发明的目的是提供一种新的抗肿瘤剂，其通过评估在某些胺化合物的存在下通过聚合丙交酯制备的聚乳酸的混合物获得的抗肿瘤效果。 本发明提供一种抗肿瘤剂，其含有下述通式（1）或（2）表示的直链状和环状的乳酸低聚物的混合物：其中，m表示1〜30的整数，n表示1〜30的整数 在下式（3）表示的化合物存在下聚合丙交酯而制备：<？in-line-formula description =“In-line formula”end =“lead”？> Me-N（R' （3）式（3）其中Me表示碱金属，其中Me表示碱金属 ，R 1和R 2各自独立地表示脂族基团或芳族基团。
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公开(公告)号：US06734214B1
公开(公告)日：2004-05-11
申请号：US10030170
申请日：2002-04-22
IPC分类号： A61K3119
CPC分类号： A61K31/765 , Y10S514/866
摘要： The object of the present invention is to provide a medicament for prevention and/or treatment of diabetes or diabetes complications, which has an action of reducing the blood sugar level. The present invention provides a medicament for prevention and/or treatment of diabetes or diabetes complications which comprises, as an active ingredient, a mixture of cyclic and/or straight chain poly lactic acids having a condensation degree of 3 to 19.
摘要翻译： 本发明的目的是提供一种用于预防和/或治疗糖尿病或糖尿病并发症的药物，其具有降低血糖水平的作用。 本发明提供了用于预防和/或治疗糖尿病或糖尿病并发症的药物，其包含作为活性成分的缩合度为3至19的环和/或直链聚乳酸的混合物。
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