发明申请
US20050107472A1 Napthoquinone derivatives as inhibitors of tau aggregation for the treatment of alzheimer's and related neurodegenerative disorders
有权
萘醌衍生物作为tau聚集的抑制剂用于治疗阿尔茨海默病和相关的神经变性疾病
- 专利标题： Napthoquinone derivatives as inhibitors of tau aggregation for the treatment of alzheimer's and related neurodegenerative disorders
- 专利标题（中）： 萘醌衍生物作为tau聚集的抑制剂用于治疗阿尔茨海默病和相关的神经变性疾病
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申请号： US10483266申请日： 2002-07-16
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公开(公告)号： US20050107472A1公开(公告)日： 2005-05-19
- 发明人: Claude Wischik , David Horsley , Janet Rickard , Charles Harrington
- 申请人： Claude Wischik , David Horsley , Janet Rickard , Charles Harrington
- 申请人地址： GB Aberdeen, Grampian AB24 3FX
- 专利权人： The University Court of the University of Aberdeen
- 当前专利权人： The University Court of the University of Aberdeen
- 当前专利权人地址： GB Aberdeen, Grampian AB24 3FX
- 优先权： GB0117326.9 20010716
- 国际申请： PCT/GB02/03269 WO 20020716
- 主分类号： A61P1/16
- IPC分类号： A61P1/16 ; A61K31/122 ; A61K31/192 ; A61K31/222 ; A61K31/255 ; A61P3/10 ; A61P7/02 ; A61P9/00 ; A61P25/00 ; A61P25/14 ; A61P25/16 ; A61P25/28 ; A61P29/00 ; A61P31/00 ; A61P35/00 ; A61P43/00 ; C07C50/10 ; C07C50/14 ; C07C50/24 ; C07C50/32 ; C07C50/38 ; C07C65/11 ; C07C69/16 ; C07C255/52 ; C07C305/22 ; C07C309/25 ; A61K31/185 ; A61K31/12 ; A61K31/19
摘要：
Provided are napthoquinone-type compounds which can be used to modulate the aggregation of protein (e.g. tau) associated with neurodegenerative disease (e.g. Alzheimer's disease). Structure-function characteristics for oxidised and reduced napthoquinone-type compounds, such as menadione-related compounds, are disclosed. The invention further provides methods of treatment or prophylaxis of neurodegenerative diseases and/or clinical dementias based on the compounds.
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