发明申请
- 专利标题： Hepatitis A vaccines
- 专利标题（中）： 甲型肝炎疫苗
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申请号： US10878094申请日： 2004-06-28
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公开(公告)号： US20050112144A1公开(公告)日： 2005-05-26
- 发明人: Erik D'Hondt
- 申请人： Erik D'Hondt
- 专利权人： SmithKline Beecham Biologicals S.A.
- 当前专利权人： SmithKline Beecham Biologicals S.A.
- 优先权： GB9822714.3 19981016
- 主分类号： C12N7/06
- IPC分类号： C12N7/06 ; A61K39/29 ; A61K39/295 ; A61P1/16 ; A61P31/12 ; C12N7/02
摘要：
A process for the production of inactivated Hepatitis A virus substantially free of host cell contamination is described, the process comprising: a)culturing Hepatitis A virus and harvesting a Hepatitis A preparation; b) treating said Hepatitis A preparation with a protease; and thereafter c) separating intact virus from protease-digested material; d) inactivating said virus. Also described are vaccines comprising the inactivated Hepatitis A virus, preferably in combination with strong adjuvants.
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