发明申请
US20050113315A1 Glucopyranosyloxybenzylbenzene derivatives, medicinal compositions containing the same and intermediates in the production thereof
审中-公开
吡喃葡萄糖氧基苄基苯衍生物,含有它们的药物组合物及其制备中间体
- 专利标题: Glucopyranosyloxybenzylbenzene derivatives, medicinal compositions containing the same and intermediates in the production thereof
- 专利标题(中): 吡喃葡萄糖氧基苄基苯衍生物,含有它们的药物组合物及其制备中间体
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申请号: US10978331申请日: 2004-11-02
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公开(公告)号: US20050113315A1公开(公告)日: 2005-05-26
- 发明人: Hideki Fujikura , Toshihiro Nishimura , Nobuhiko Fushimi , Kazuya Tatani , Norihiko Kikuchi , Kenji Katsuno , Masayuki Isaji
- 申请人: Hideki Fujikura , Toshihiro Nishimura , Nobuhiko Fushimi , Kazuya Tatani , Norihiko Kikuchi , Kenji Katsuno , Masayuki Isaji
- 专利权人: KISSEI PHARMACEUTICAL CO., LTD.
- 当前专利权人: KISSEI PHARMACEUTICAL CO., LTD.
- 优先权: JP366192/2000 20001130; JP380482/2000 20001214
- 主分类号: A61P3/04
- IPC分类号: A61P3/04 ; A61P3/10 ; A61P43/00 ; C07H15/203 ; A61K31/704 ; C07H5/04
摘要:
The present invention relates to glucopyranosyloxybenzylbenzene derivatives represented by the general formula: wherein R1 represents a hydrogen atom, a hydroxy group, a substituted or unsubstituted amino group, a carbamoyl group, a substituted or unsubstituted(lower alkyl) group, a substituted or unsubstituted(lower alkoxy) group etc.; R2 represents a hydrogen atom or a lower alkyl group; and R3 represents a substituted or unsubstituted(lower alkyl) group, a substituted or unsubstituted(lower alkoxy) group, a substituted or unsubstituted(lower alkylthio) group etc., or pharmaceutically acceptable salts thereof, which have an inhibitory activity in human SGLT2 and are useful as agents for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, diabetic complication or obesity, pharmaceutical compositions comprising the same and intermediates thereof.