发明申请
US20050113379A1 Heteroaryl fused pyridines, pyrazines and pyrimidines as CRF1 receptor ligands
审中-公开
杂芳基稠合吡啶，吡嗪和嘧啶作为CRF1受体配体
- 专利标题： Heteroaryl fused pyridines, pyrazines and pyrimidines as CRF1 receptor ligands
- 专利标题（中）： 杂芳基稠合吡啶，吡嗪和嘧啶作为CRF1受体配体
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申请号： US10933834申请日： 2004-09-03
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公开(公告)号： US20050113379A1公开(公告)日： 2005-05-26
- 发明人: Ping Ge , Raymond Horvath , Lu Yan Zhang , Yasuchika Yamaguchi , Bernd Kaiser , Xuechun Zhang , Suoming Zhang , He Zhao , Stanly John , Neil Moorcroft , Greg Shutske
- 申请人： Ping Ge , Raymond Horvath , Lu Yan Zhang , Yasuchika Yamaguchi , Bernd Kaiser , Xuechun Zhang , Suoming Zhang , He Zhao , Stanly John , Neil Moorcroft , Greg Shutske
- 主分类号： A61K31/437
- IPC分类号： A61K31/437 ; A61K31/4375 ; A61K31/4985 ; C07D471/04 ; C07D487/04 ; C07D519/00 ; A61K31/519 ; A61K31/522 ; C07D473/02 ; C07D491/02 ; C07D498/02
摘要：
Substituted heteroaryl fused pyridine, pyrazine, and pyrimidine compounds that act as selective modulators of CRF 1 receptors are provided. These compounds are useful in the treatment of a number of CNS and periphereal disorders, particularly stress, anxiety, depression, cardiovascular disorders, and eating disorders. Methods of treatment of such disorders and well as packaged pharmaceutical compositions are also provided. Compounds of the invention are also useful as probes for the localization of CRF receptors and as standards in assays for CRF receptor binding. Methods of using the compounds in receptor localization studies are given.
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