发明申请
US20050118266A1 Sustained/controlled release solid formulation as a novel drug delivery system with reduced risk of dose dumping
审中-公开
持续/控制释放的固体制剂作为具有降低的剂量倾倒风险的新型药物递送系统
- 专利标题： Sustained/controlled release solid formulation as a novel drug delivery system with reduced risk of dose dumping
- 专利标题（中）： 持续/控制释放的固体制剂作为具有降低的剂量倾倒风险的新型药物递送系统
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申请号： US10504014申请日： 2002-03-27
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公开(公告)号： US20050118266A1公开(公告)日： 2005-06-02
- 发明人: M.Z.I. Khan , Aleksandra Krajacic , Zdravka Knezevic , Snjezana Vodopija-Mandic
- 申请人： M.Z.I. Khan , Aleksandra Krajacic , Zdravka Knezevic , Snjezana Vodopija-Mandic
- 优先权： HRP20020124A 20020211
- 国际申请： PCT/HR02/00018 WO 20020327
- 主分类号： A61K9/22
- IPC分类号： A61K9/22 ; A61K9/16 ; A61K9/20 ; A61K9/28 ; A61K9/36 ; A61K31/196 ; A61K31/341 ; A61K31/64 ; A61K31/4172 ; A61K9/26
摘要：
A sustained/controlled release formulation with reduced risk of dose dumping and side effects combines two components: component (a) comprises a pharmaceutically active agent and a water-insoluble, but water-permeable polymer, whereas component (b) comprises a pharmaceutically active agent and a hydrophobic material. By changing the ratio of a pharmaceutically active agent and water-insoluble, but water-permeable polymer comprised in the component (a) and/or the ratio of the pharmaceutically active agent and hydrophobic material comprised in the component (b), and ideal release rate, with reduced risk of dose dumping and side effects, can easily be achieved.
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