公开(公告)号：US20050118266A1

公开(公告)日：2005-06-02

申请号：US10504014

申请日：2002-03-27

申请人： M.Z.I. Khan ,  Aleksandra Krajacic ,  Zdravka Knezevic ,  Snjezana Vodopija-Mandic

发明人： M.Z.I. Khan ,  Aleksandra Krajacic ,  Zdravka Knezevic ,  Snjezana Vodopija-Mandic

IPC分类号： A61K9/22 ,  A61K9/16 ,  A61K9/20 ,  A61K9/28 ,  A61K9/36 ,  A61K31/196 ,  A61K31/341 ,  A61K31/64 ,  A61K31/4172 ,  A61K9/26

CPC分类号： A61K9/2077 ,  A61K9/1635 ,  A61K9/2866

摘要： A sustained/controlled release formulation with reduced risk of dose dumping and side effects combines two components: component (a) comprises a pharmaceutically active agent and a water-insoluble, but water-permeable polymer, whereas component (b) comprises a pharmaceutically active agent and a hydrophobic material. By changing the ratio of a pharmaceutically active agent and water-insoluble, but water-permeable polymer comprised in the component (a) and/or the ratio of the pharmaceutically active agent and hydrophobic material comprised in the component (b), and ideal release rate, with reduced risk of dose dumping and side effects, can easily be achieved.

摘要翻译： 具有降低的倾倒风险和副作用的持续/控释制剂组合了两个组分：组分（a）包含药物活性剂和水不溶性但水可渗透的聚合物，而组分（b）包含药物活性剂 和疏水性材料。 通过改变组分（a）中包含的药物活性剂和水不溶性但水可渗透的聚合物的比例和/或组分（b）中包含的药物活性剂和疏水性物质的比例和理想释放量 速率，减少倾倒的风险和副作用，可以很容易地实现。