发明申请
- 专利标题： Tetronic and tetramic acids
- 专利标题（中）： 季戊四醇和四酸
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申请号： US10994823申请日： 2004-11-22
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公开(公告)号： US20050119329A1公开(公告)日： 2005-06-02
- 发明人: Thierry Godel , Hans Hilpert , Roland Humm , Mark Rogers-Evans , Didier Rombach , Christoph Stahl , Peter Weiss , Wolfgang Wostl
- 申请人： Thierry Godel , Hans Hilpert , Roland Humm , Mark Rogers-Evans , Didier Rombach , Christoph Stahl , Peter Weiss , Wolfgang Wostl
- 优先权： EP03104437.3 20031128
- 主分类号： C07D207/38
- IPC分类号： C07D207/38 ; C07D307/60 ; C07D401/06 ; C07D403/06 ; C07D405/06 ; C07D409/06 ; C07D417/06 ; C07D495/06 ; C07D45/02 ; A61K31/365 ; A61K31/4015 ; A61K31/4025
摘要：
This invention relates to new tetronic and tetramic acid derivatives with beta-secretase inhibitory activity of formula I: wherein R1, R2, R3, R4, R5, R5′, R6 and R6′ are as defined hereinabove, to processes for their preparation, compositions containing said tetronic and tetramic acid derivatives and their use in the treatment and prevention of diseases modulated by an inhibitor of β-secretase, such as Alzheimer's disease.
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