发明申请
- 专利标题： Hepatocellular carcinoma specific promoter and uses thereof
- 专利标题（中）： 肝细胞癌特异性启动子及其用途
-
申请号： US10947812申请日： 2004-09-22
-
公开(公告)号： US20050124068A1公开(公告)日： 2005-06-09
- 发明人: Trini Arroyo , Yuanhao Li
- 申请人： Trini Arroyo , Yuanhao Li
- 专利权人： Cell Genesys, Inc.
- 当前专利权人： Cell Genesys, Inc.
- 主分类号： A61K35/76
- IPC分类号： A61K35/76 ; A61K35/761 ; A61K48/00 ; C07H21/04 ; C12N5/08 ; C12N7/00 ; C12N15/861
摘要：
Liver cancer, particularly hepatocellular carcinoma specific promoter sequences and adenovirus vehicles are provided. By providing for transcriptional initiating regulation dependent upon transcription factors that are only active in specific, limited cell types, virus replication will be restricted to the target cells. The modified adenovirus may be used as a vehicle for introducing new genetic capability, particularly associated with cytotoxicity, for treating neoplasia.
公开/授权文献
- US07482156B2 Hepatocellular carcinoma specific promoter and uses thereof 公开/授权日：2009-01-27