发明申请
- 专利标题: Polymer conjugates of mutated neublastin
- 专利标题(中): 突变型新伯斯汀的聚合物缀合物
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申请号: US10356264申请日: 2003-01-31
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公开(公告)号: US20050142098A1公开(公告)日: 2005-06-30
- 发明人: Dinah Sah , R. Pepinsky , Paula Boriack-Sjodin , Stephan Miller , Anthony Rossomando , Laura Silvian
- 申请人: Dinah Sah , R. Pepinsky , Paula Boriack-Sjodin , Stephan Miller , Anthony Rossomando , Laura Silvian
- 主分类号: A61K6/00
- IPC分类号: A61K6/00 ; A61K38/00 ; A61K38/18 ; A61K39/00 ; A61K47/48 ; A61P25/02 ; A61P25/04 ; C07K20060101 ; C07K14/00 ; C07K14/475 ; C12N15/12 ; C12N15/18 ; C08G63/48 ; C08G63/91
摘要:
A dimer comprising a mutated neublastin polypeptide coupled to a polymer is disclosed. Such dimers exhibit prolonged bioavailability and, in preferred embodiments, prolonged biological activity relative to wild-type forms of neublastin.
公开/授权文献
- US07442370B2 Polymer conjugates of mutated neublastin 公开/授权日:2008-10-28
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