Invention Application
US20050142148A1 Recombinant parainfluenza virus expression systems and vaccines comprising heterologous antigens derived from metapneumovirus 审中-公开
重组副流感病毒表达系统和包含源自偏肺病毒的异源抗原的疫苗

Recombinant parainfluenza virus expression systems and vaccines comprising heterologous antigens derived from metapneumovirus
Abstract:
The present invention relates to recombinant bovine parainfluenza virus (bPIV) cDNA or RNA which may be used to express heterologous gene products in appropriate host cell systems and/or to rescue negative strand RNA recombinant viruses that express, package, and/or present the heterologous gene product. In particular, the heterologous gene products include gene product of another species of PIV or from another negative strand RNA virus, including but not limited to, influenza virus, respiratory syncytial virus, human metapneumovirus and avian pneumovirus. The chimeric viruses and expression products may advantageously be used in vaccine formulations including vaccines against a broad range of pathogens and antigens.
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