Invention Application
- Patent Title: Recombinant parainfluenza virus expression systems and vaccines comprising heterologous antigens derived from metapneumovirus
- Patent Title (中): 重组副流感病毒表达系统和包含源自偏肺病毒的异源抗原的疫苗
-
Application No.: US10831781Application Date: 2004-04-23
-
Publication No.: US20050142148A1Publication Date: 2005-06-30
- Inventor: Ronaldus Fouchier , Bernadetta Van Den Hoogen , Albertus Dominicus Erasmus Osterhaus , Aurelia Haller , Roderick Tang
- Applicant: Ronaldus Fouchier , Bernadetta Van Den Hoogen , Albertus Dominicus Erasmus Osterhaus , Aurelia Haller , Roderick Tang
- Main IPC: A61K
- IPC: A61K20060101 ; A61K39/12 ; A61K39/155 ; C07K14/115 ; C07K14/135 ; C12N7/00 ; C12N15/44 ; C12N15/86

Abstract:
The present invention relates to recombinant bovine parainfluenza virus (bPIV) cDNA or RNA which may be used to express heterologous gene products in appropriate host cell systems and/or to rescue negative strand RNA recombinant viruses that express, package, and/or present the heterologous gene product. In particular, the heterologous gene products include gene product of another species of PIV or from another negative strand RNA virus, including but not limited to, influenza virus, respiratory syncytial virus, human metapneumovirus and avian pneumovirus. The chimeric viruses and expression products may advantageously be used in vaccine formulations including vaccines against a broad range of pathogens and antigens.
Information query