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1.发明授权Metapneumovirus strains and their use in vaccine formulations and sequences 有权肺炎病毒菌株及其在疫苗制剂中的用途以及用于表达抗原序列的载体公开(公告)号：US08722341B2
公开(公告)日：2014-05-13
申请号：US12319152
申请日：2008-12-31
申请人： Ronaldus Adrianus Maria Fouchier , Bernadetta Gerarda Van Den Hoogen , Albertus Dominicus Marcellinus Erasmus Osterhaus , Aurelia Haller , Roderick Tang
发明人： Ronaldus Adrianus Maria Fouchier , Bernadetta Gerarda Van Den Hoogen , Albertus Dominicus Marcellinus Erasmus Osterhaus , Aurelia Haller , Roderick Tang
CPC分类号： C12Q1/701 , A61K39/12 , A61K39/155 , A61K2039/5254 , A61K2039/5256 , C07K14/005 , C07K16/1027 , C12N7/00 , C12N15/86 , C12N2760/18321 , C12N2760/18322 , C12N2760/18334 , C12N2760/18343 , C12N2760/18622 , C12N2840/203 , C12Q2600/158 , G01N33/5008 , G01N33/502 , G01N33/5091 , G01N33/56983
摘要： Provided is an isolated mammalian negative strand RNA virus, metapneumovirus (MPV). Described are isolated mammalian negative strand RNA viruses identifiable as phylogenetically corresponding or relating to the genus Metapneumovirus and components thereof. Also described is mammalian MPV, subgroups and variants thereof, and genomic nucleotide sequences of different isolates of mammalian metapneumoviruses, in particular human metapneumoviruses. The use of the sequence information of different isolates of mammalian metapneumoviruses for diagnostic and therapeutic methods is provided. Nucleotide sequences encoding the genome of a metapneumovirus or a portion thereof, including both mammalian and avian metapneumovirus are described. Also provided are chimeric or recombinant viruses encoded by said nucleotide sequences and chimeric and recombinant mammalian MPV that comprise one or more non-native or heterologous sequences.
摘要翻译： 提供了分离的哺乳动物负链RNA病毒，偏肺病毒（MPV）。 描述的是分离的哺乳动物负链RNA病毒，其被鉴定为与肺炎病毒属及其组分相关或与之相关的系统发育。 还描述了哺乳动物MPV，亚组及其变体，以及哺乳动物偏肺病毒，特别是人类偏肺病毒的不同分离物的基因组核苷酸序列。 提供了用于诊断和治疗方法的哺乳动物偏肺炎病毒的不同分离株的序列信息的使用。 描述了编码偏肺病毒或其部分基因组的核苷酸序列，包括哺乳动物和禽类间质肺病毒。 还提供了由所述核苷酸序列编码的嵌合或重组病毒以及包含一个或多个非天然或异源序列的嵌合和重组哺乳动物MPV。
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公开(公告)号：US08084037B2
公开(公告)日：2011-12-27
申请号：US12694366
申请日：2010-01-27
申请人： Aurelia Haller , Kathleen Coelingh
发明人： Aurelia Haller , Kathleen Coelingh
IPC分类号： A61K39/00
CPC分类号： C12N15/86 , A61K39/12 , A61K39/155 , A61K2039/5256 , A61K2039/53 , C12N7/00 , C12N2760/18621 , C12N2760/18634 , C12N2760/18643 , C12N2760/18661
摘要： The present invention relates to recombinant bovine parainfluenza virus (bPIV) cDNA or RNA which may be used to express heterologous gene products in appropriate host cell systems and/or to rescue negative strand RNA recombinant viruses that express, package, and/or present the heterologous gene product. The chimeric viruses and expression products may advantageously be used in vaccine formulations including vaccines against a broad range of pathogens and antigens.
摘要翻译： 本发明涉及可用于在合适的宿主细胞系统中表达异源基因产物的重组牛副流感病毒（bPIV）cDNA或RNA，和/或挽救表达，包装和/或呈递异源的负链RNA重组病毒 基因产物。 嵌合病毒和表达产物可有利地用于疫苗制剂中，包括针对各种病原体和抗原的疫苗。
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公开(公告)号：US20100150963A1
公开(公告)日：2010-06-17
申请号：US12631039
申请日：2009-12-04
CPC分类号： A61K39/29 , A61K39/12 , A61K2039/521 , A61K2039/523 , A61K2039/5252 , C07K14/005 , C07K2319/35 , C12N2770/24222 , C12N2770/24234
摘要： Disclosed are compositions, including vaccines, and methods for vaccinating an animal against hepatitis C virus (HCV) and for treating or preventing hepatitis C viral infection in an animal. The invention includes a variety of novel HCV fusion proteins that can be used directly as a vaccine or in conjunction with a yeast-based vaccine vehicle to elicit an immune response against HCV in an animal. The invention also includes the use of the HCV fusion gene and protein described herein in any diagnostic or therapeutic protocol for the detection and/or treatment or prevention of HCV infection.
摘要翻译： 公开了包括疫苗和疫苗接种丙型肝炎病毒（HCV）的组合物和用于治疗或预防动物中的丙型肝炎病毒感染的组合物。 本发明包括可以直接用作疫苗或与基于酵母的疫苗载体一起使用以在动物中引发针对HCV的免疫应答的多种新型HCV融合蛋白。 本发明还包括本文所述的HCV融合基因和蛋白质在任何诊断或治疗方案中用于检测和/或治疗或预防HCV感染的用途。
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4.发明申请Metapneumovirus strains and their use in vaccine formulations and as vectors for expression of antigenic sequences 有权肺炎病毒菌株及其在疫苗制剂中的用途以及用于表达抗原序列的载体公开(公告)号：US20100143407A1
公开(公告)日：2010-06-10
申请号：US12319152
申请日：2008-12-31
申请人： Ronaldus Adrianus Maria Fouchier , Benadetta Gerarda Van Den Hoogen , Albertus Dominicus Marcellinus Erasmus Osterhaus , Aurelia Haller , Roderick Tang
发明人： Ronaldus Adrianus Maria Fouchier , Benadetta Gerarda Van Den Hoogen , Albertus Dominicus Marcellinus Erasmus Osterhaus , Aurelia Haller , Roderick Tang
CPC分类号： C12Q1/701 , A61K39/12 , A61K39/155 , A61K2039/5254 , A61K2039/5256 , C07K14/005 , C07K16/1027 , C12N7/00 , C12N15/86 , C12N2760/18321 , C12N2760/18322 , C12N2760/18334 , C12N2760/18343 , C12N2760/18622 , C12N2840/203 , C12Q2600/158 , G01N33/5008 , G01N33/502 , G01N33/5091 , G01N33/56983
摘要： The present invention provides an isolated mammalian negative strand RNA virus, metapneumovirus (MPV), within the sub-family Pneumoviridae, of the family Paramyxoviridae. The invention also provides isolated mammalian negative strand RNA viruses identifiable as phylogenetically corresponding or relating to the genus Metapneumovirus and components thereof. In particular the invention provides a mammalian MPV, subgroups and variants thereof. The invention relates to genomic nucleotide sequences of different isolates of mammalian metapneumoviruses, in particular human metapneumoviruses. The invention relates to the use of the sequence information of different isolates of mammalian metapneumoviruses for diagnostic and therapeutic methods. The present invention relates to nucleotide sequences encoding the genome of a metapneumovirus or a portion thereof, including both mammalian and avian metapneumovirus. The invention further encompasses chimeric or recombinant viruses encoded by said nucleotide sequences. The invention also relates to chimeric and recombinant mammalian MPV that comprise one or more non-native or heterologous sequences. The invention further relates to vaccine formulations comprising mammalian or avian metapneumovirus, including recombinant and chimeric forms of said viruses. The vaccine preparations of the invention encompass multivalent vaccines, including bivalent and trivalent vaccine preparations.
摘要翻译： 本发明提供分离的哺乳动物负链RNA病毒，亚型家族肺炎链球菌中的亚型副粘病毒亚科病毒（MPV）。 本发明还提供可分离的哺乳动物负链RNA病毒，其可鉴定为与肺炎病毒属及其组分相关或与之相关的系统发育。 特别地，本发明提供哺乳动物MPV，亚组及其变体。 本发明涉及哺乳动物偏肺炎病毒，特别是人类偏肺病毒的不同分离物的基因组核苷酸序列。 本发明涉及用于诊断和治疗方法的哺乳动物偏肺病毒的不同分离株的序列信息的使用。 本发明涉及编码偏肺病毒或其部分基因组的核苷酸序列，包括哺乳动物和禽类间质肺病毒。 本发明还包括由所述核苷酸序列编码的嵌合或重组病毒。 本发明还涉及包含一种或多种非天然或异源序列的嵌合和重组哺乳动物MPV。 本发明还涉及包含哺乳动物或禽类偏肺病毒的疫苗制剂，包括所述病毒的重组和嵌合形式。 本发明的疫苗制剂包括多价疫苗，包括二价和三价疫苗制剂。
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公开(公告)号：US20060110755A1
公开(公告)日：2006-05-25
申请号：US11254252
申请日：2005-10-18
申请人： Richard Duke , Alex Franzusoff , Aurelia Haller , Thomas King
发明人： Richard Duke , Alex Franzusoff , Aurelia Haller , Thomas King
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/29 , A61K2039/523 , A61K2039/5252 , A61K2039/55516 , C12N2770/24222 , C12N2770/24234
摘要： Disclosed are compositions, including vaccines, and methods for vaccinating an animal against hepatitis C virus (HCV) and for treating or preventing hepatitis C viral infection in an animal. The invention includes a variety of novel HCV fusion proteins that can be used directly as a vaccine or in conjunction with a yeast-based vaccine vehicle to elicit an immune response against HCV in an animal. The invention also includes the use of the HCV fusion gene and protein described herein in any diagnostic or therapeutic protocol for the detection and/or treatment or prevention of HCV infection.
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公开(公告)号：US08007816B2
公开(公告)日：2011-08-30
申请号：US12196439
申请日：2008-08-22
申请人： Richard C Duke , Alex Franzusoff , Aurelia Haller , Thomas H King
发明人： Richard C Duke , Alex Franzusoff , Aurelia Haller , Thomas H King
CPC分类号： A61K39/29 , A61K39/12 , A61K2039/521 , A61K2039/523 , A61K2039/5252 , C07K14/005 , C07K2319/35 , C12N2770/24222 , C12N2770/24234
摘要： Disclosed are compositions, including vaccines, and methods for vaccinating an animal against hepatitis C virus (HCV) and for treating or preventing hepatitis C viral infection in an animal. The invention includes a variety of novel HCV fusion proteins that can be used directly as a vaccine or in conjunction with a yeast-based vaccine vehicle to elicit an immune response against HCV in an animal. The invention also includes the use of the HCV fusion gene and protein described herein in any diagnostic or therapeutic protocol for the detection and/or treatment or prevention of HCV infection.
摘要翻译： 公开了包括疫苗和疫苗接种丙型肝炎病毒（HCV）的组合物和用于治疗或预防动物中的丙型肝炎病毒感染的组合物。 本发明包括可以直接用作疫苗或与基于酵母的疫苗载体一起使用以在动物中引发针对HCV的免疫应答的多种新型HCV融合蛋白。 本发明还包括本文所述的HCV融合基因和蛋白质在任何诊断或治疗方案中用于检测和/或治疗或预防HCV感染的用途。
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公开(公告)号：US20100119547A1
公开(公告)日：2010-05-13
申请号：US12694366
申请日：2010-01-27
IPC分类号： A61K39/155 , C07H21/02 , A61P31/16 , C07H21/04 , C12N7/01
CPC分类号： C12N15/86 , A61K39/12 , A61K39/155 , A61K2039/5256 , A61K2039/53 , C12N7/00 , C12N2760/18621 , C12N2760/18634 , C12N2760/18643 , C12N2760/18661
摘要： The present invention relates to recombinant bovine parainfluenza virus (bPIV) cDNA or RNA which may be used to express heterologous gene products in appropriate host cell systems and/or to rescue negative strand RNA recombinant viruses that express, package, and/or present the heterologous gene product. The chimeric viruses and expression products may advantageously be used in vaccine formulations including vaccines against a broad range of pathogens and antigens.
摘要翻译： 本发明涉及可用于在合适的宿主细胞系统中表达异源基因产物的重组牛副流感病毒（bPIV）cDNA或RNA，和/或挽救表达，包装和/或呈递异源的负链RNA重组病毒 基因产物。 嵌合病毒和表达产物可有利地用于疫苗制剂中，包括针对各种病原体和抗原的疫苗。
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公开(公告)号：US07632511B2
公开(公告)日：2009-12-15
申请号：US11618834
申请日：2006-12-31
CPC分类号： A61K39/29 , A61K39/12 , A61K2039/521 , A61K2039/523 , A61K2039/5252 , C07K14/005 , C07K2319/35 , C12N2770/24222 , C12N2770/24234
摘要： Disclosed are compositions, including vaccines, and methods for vaccinating an animal against hepatitis C virus (HCV) and for treating or preventing hepatitis C viral infection in an animal. The invention includes a variety of novel HCV fusion proteins that can be used directly as a vaccine or in conjunction with a yeast-based vaccine vehicle to elicit an immune response against HCV in an animal. The invention also includes the use of the HCV fusion gene and protein described herein in any diagnostic or therapeutic protocol for the detection and/or treatment or prevention of HCV infection.
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公开(公告)号：US20090074805A1
公开(公告)日：2009-03-19
申请号：US12196439
申请日：2008-08-22
CPC分类号： A61K39/29 , A61K39/12 , A61K2039/521 , A61K2039/523 , A61K2039/5252 , C07K14/005 , C07K2319/35 , C12N2770/24222 , C12N2770/24234
摘要： Disclosed are compositions, including vaccines, and methods for vaccinating an animal against hepatitis C virus (HCV) and for treating or preventing hepatitis C viral infection in an animal. The invention includes a variety of novel HCV fusion proteins that can be used directly as a vaccine or in conjunction with a yeast-based vaccine vehicle to elicit an immune response against HCV in an animal. The invention also includes the use of the HCV fusion gene and protein described herein in any diagnostic or therapeutic protocol for the detection and/or treatment or prevention of HCV infection.
摘要翻译： 公开了包括疫苗和疫苗接种丙型肝炎病毒（HCV）的组合物和用于治疗或预防动物中的丙型肝炎病毒感染的组合物。 本发明包括可以直接用作疫苗或与基于酵母的疫苗载体一起使用以在动物中引发针对HCV的免疫应答的多种新型HCV融合蛋白。 本发明还包括本文所述的HCV融合基因和蛋白质在任何诊断或治疗方案中用于检测和/或治疗或预防HCV感染的用途。
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10.发明申请Recombinant Parainfluenza Virus Expression Systems And Vaccines Comprising Heterologous Antigens Derived From Respiratory Syncytial Virus 审中-公开重组副流感病毒表达系统和疫苗，其包含来自呼吸道合胞病毒的异源抗原公开(公告)号：US20080096263A1
公开(公告)日：2008-04-24
申请号：US11762814
申请日：2007-06-14
申请人： Aurelia Haller , Kathleen Coelingh
发明人： Aurelia Haller , Kathleen Coelingh
IPC分类号： C12N7/00
CPC分类号： C12Q1/701 , A61K39/12 , A61K39/155 , A61K2039/5254 , A61K2039/5256 , A61K2039/545 , A61K2039/552 , A61K2039/58 , A61K2039/70 , A61K2123/00 , C07K14/005 , C07K16/1027 , C12N7/00 , C12N15/86 , C12N2710/22034 , C12N2760/18321 , C12N2760/18322 , C12N2760/18334 , C12N2760/18343 , C12N2760/18522 , C12N2760/18534 , C12N2760/18621 , C12N2760/18622 , C12N2760/18634 , C12N2760/18643 , C12N2840/203 , C12Q2600/158 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/5088 , G01N33/56983 , G01N2333/08 , Y02A90/26
摘要： The present invention relates to recombinant bovine parainfluenza virus (bPIV) cDNA or RNA which may be used to express heterologous gene products in appropriate host cell systems and/or to rescue negative strand RNA recombinant viruses that express, package, and/or present the heterologous gene product. In particular, the heterologous gene products include gene product of another species of PIV or from another negative strand RNA virus, including but not limited to, influenza virus, respiratory syncytial virus, human metapneumovirus and avian pneumovirus. The chimeric viruses and expression products may advantageously be used in vaccine formulations including vaccines against a broad range of pathogens and antigens.
摘要翻译： 本发明涉及可用于在合适的宿主细胞系统中表达异源基因产物的重组牛副流感病毒（bPIV）cDNA或RNA，和/或挽救表达，包装和/或呈递异源的负链RNA重组病毒 基因产物。 特别地，异源基因产物包括另一种PIV或另一种负链RNA病毒的基因产物，包括但不限于流感病毒，呼吸道合胞病毒，人偏肺病毒和禽肺病毒。 嵌合病毒和表达产物可有利地用于疫苗制剂中，包括针对各种病原体和抗原的疫苗。
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