发明申请
- 专利标题: Process
- 专利标题(中): 处理
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申请号: US11002864申请日: 2004-12-02
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公开(公告)号: US20050152840A1公开(公告)日: 2005-07-14
- 发明人: Oskar Axelsson , Charlotte Olofsson , Axel Morgenstjerne , Georg Hansson , Haukur Johannesson , Jan-Henrik Ardenkjaer-Larsen
- 申请人: Oskar Axelsson , Charlotte Olofsson , Axel Morgenstjerne , Georg Hansson , Haukur Johannesson , Jan-Henrik Ardenkjaer-Larsen
- 优先权: GB9911681.6 19990519
- 主分类号: A61K49/00
- IPC分类号: A61K49/00 ; A61K49/18 ; C07C67/303 ; C07C69/675 ; G01R33/28 ; G01R33/483
摘要:
The present invention provides a process for the preparation of an MR contrast agent, said process comprising: i) obtaining a solution in a solvent of a hydrogenatable, unsaturated substrate compound and a catalyst for the hydrogenation of said substrate compound; ii) introducing said solution in droplet form into a chamber containing hydrogen gas (H2) enriched in para-hydrogen (p-1H2) and/or ortho-deuterium (o-2H2) whereby to hydrogenate said substrate to form a hydrogenated imaging agent; iii) optionally subjecting said hydrogenated imaging agent to a magnetic field having a field strength below earth's ambient field strength; iv) optionally dissolving said imaging agent in an aqueous medium; v) optionally separating said catalyst from the solution of said imaging agent in said aqueous medium; vi) optionally separating said solvent from the solution of said imaging agent in said aqueous medium; and vii) optionally freezing the solution of said imaging agent in said aqueous medium.
公开/授权文献
- US07459144B2 Process for preparation of MR contrast agents 公开/授权日:2008-12-02