公开(公告)号：US12030852B2

公开(公告)日：2024-07-09

申请号：US17378967

申请日：2019-01-23

Applicant: IOI Oleo GmbH

Inventor： Dirk Lochmann ,  Sebastian Reyer ,  Michael Stehr

IPC: C07C67/02 ,  C07C67/03 ,  C07C67/08 ,  C07C69/675 ,  C07C69/732 ,  C12P7/62

CPC classification number: C07C69/675 ,  C07C67/02 ,  C07C67/03 ,  C07C67/08 ,  C07C69/732 ,  C12P7/62 ,  C12Y301/01

Abstract: The invention relates to a method for producing fatty alcohol esters of 3-hydroxybutyric acid and their acylated derivatives, as well as the products thus obtained and their use.

公开(公告)号：US11999757B2

公开(公告)日：2024-06-04

申请号：US16760369

申请日：2018-10-30

Applicant: MELINTA SUBSIDIARY CORP.

Inventor： Serge Henri Boyer ,  Scott J. Hecker ,  Gerardus K. M. Verzijl ,  Petrus J. Hermsen

IPC: C07F5/02 ,  B01J23/46 ,  C07C67/31 ,  C07C69/675 ,  C07F5/04 ,  C12P9/00

CPC classification number: C07F5/025 ,  B01J23/462 ,  C07C67/31 ,  C07C69/675 ,  C07F5/04 ,  C12P9/00 ,  C07C67/31 ,  C07C69/675

Abstract: Disclosed herein are methods for the preparation of boronate derivatives in the synthesis of antimicrobial compounds and uses thereof. Disclosed herein includes method of making a compound of Formula (B) by reducing the ketone group of the keto-ester compound of Formula (A), and the reduction can be performed using a Ruthenium based catalyst system or using an alcohol dehydrogenase bioreduction system.

公开(公告)号：US20240150798A1

公开(公告)日：2024-05-09

申请号：US18482834

申请日：2023-10-06

Applicant: Genomatica, Inc.

Inventor： Benjamin ADELSTEIN ,  Robin E. OSTERHOUT ,  Mark J. BURK

IPC: C12P7/62 ,  A23L33/135 ,  A61K31/22 ,  A61K35/66 ,  A61K36/064 ,  C07C69/675 ,  C12N1/00 ,  C12N1/14 ,  C12N1/20 ,  C12N9/18 ,  C12N15/52

CPC classification number: C12P7/62 ,  A23L33/135 ,  A61K31/22 ,  A61K35/66 ,  A61K36/064 ,  C07C69/675 ,  C12N1/00 ,  C12N1/145 ,  C12N1/205 ,  C12N9/18 ,  C12N15/52 ,  C12Y101/01035 ,  C12Y101/011 ,  C12Y301/01067 ,  C12Y301/08001 ,  C07B2200/05 ,  C12R2001/00 ,  Y02P20/10

Abstract: Provided herein are non-naturally occurring microbial organisms having a pathway for production of (3R)-hydroxybutyl (3R)-hydroxybutyrate, wherein the organism can further include a (R)-1,3-butanediol pathway, a (3R)-hydroxybutyrate pathway, a (3R)-hydroxybutyryl-CoA pathway, an acetoacetate pathway, an acetoacetyl-CoA pathway, a (3R)-hydroxybutyl-ACP pathway, or an acetoacetyl-ACP pathway. Additionally provided are methods and processes for producing and isolating (3R)-hydroxybutyl (3R)-hydroxybutyrate using the microbial organisms, and various compositions having the (3R)-hydroxybutyl (3R)-hydroxybutyrate. Still further provided are methods of treating or preventing a disease, disorder or condition using the (3R)-hydroxybutyl (3R)-hydroxybutyrate produced by the microbial organisms of the invention.

公开(公告)号：US20240124385A1

公开(公告)日：2024-04-18

申请号：US18516407

申请日：2023-11-21

Applicant: CORSAIR PHARMA, INC.

Inventor： Xiaoming ZHANG ,  Meenakshi S. VENKATRAMAN ,  Cyrus K. BECKER

IPC: C07C69/734 ,  A61K9/70 ,  C07C53/136 ,  C07C59/11 ,  C07C59/13 ,  C07C69/28 ,  C07C69/675 ,  C07C69/68 ,  C07C69/708 ,  C07C69/712 ,  C07C69/74 ,  C07C69/75 ,  C07C69/96 ,  C07D305/08 ,  C07D307/24 ,  C07D307/30 ,  C07D309/08

CPC classification number: C07C69/734 ,  A61K9/7023 ,  C07C53/136 ,  C07C59/11 ,  C07C59/13 ,  C07C69/28 ,  C07C69/675 ,  C07C69/68 ,  C07C69/708 ,  C07C69/712 ,  C07C69/74 ,  C07C69/75 ,  C07C69/96 ,  C07D305/08 ,  C07D307/24 ,  C07D307/30 ,  C07D309/08 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2603/14

Abstract: The present disclosure provides treprostinil derivatives that can act as prodrugs of treprostinil. The treprostinil derivatives can be used to treat any conditions responsive to treatment with treprostinil, including pulmonary hypertension, such as pulmonary arterial hypertension.

公开(公告)号：US11814664B2

公开(公告)日：2023-11-14

申请号：US14893510

申请日：2014-05-23

Applicant: Genomatica, Inc.

Inventor： Benjamin Adelstein ,  Robin E. Osterhout ,  Mark J. Burk

IPC: C12P7/62 ,  C12N9/18 ,  A61K31/22 ,  A61K35/66 ,  A61K36/064 ,  A23L33/135 ,  C12N1/00 ,  C12N1/14 ,  C12N1/20 ,  C07C69/675 ,  C12N15/52 ,  C12R1/00 ,  C12R1/01 ,  C12R1/645

CPC classification number: C12P7/62 ,  A23L33/135 ,  A61K31/22 ,  A61K35/66 ,  A61K36/064 ,  C07C69/675 ,  C12N1/00 ,  C12N1/145 ,  C12N1/205 ,  C12N9/18 ,  C12N15/52 ,  C12Y101/011 ,  C12Y101/01035 ,  C12Y301/01067 ,  C12Y301/08001 ,  A23V2002/00 ,  C07B2200/05 ,  C12R2001/00 ,  C12R2001/01 ,  C12R2001/645 ,  Y02P20/10

Abstract: Provided herein are non-naturally occurring microbial organisms having a pathway for production of (3R)-hydroxybutyl (3R)-hydroxybutyrate, wherein the organism can further include a (R)-1,3-butanediol pathway, a (3R)-hydroxybutyrate pathway, a (3R)-hydroxybutyryl-CoA pathway, an acetoacetate pathway, an acetoacetyl-CoA pathway, a (3R)-hydroxybutyl-ACP pathway, or an acetoacetyl-ACP pathway. Additionally provided are methods and processes for producing and isolating (3R)-hydroxybutyl (3R)-hydroxybutyrate using the microbial organisms, and various compositions having the (3R)-hydroxybutyl (3R)-hydroxybutyrate. Still further provided are methods of treating or preventing a disease, disorder or condition using the (3R)-hydroxybutyl (3R)-hydroxybutyrate produced by the microbial organisms of the invention.

公开(公告)号：US20220145338A1

公开(公告)日：2022-05-12

申请号：US17582744

申请日：2022-01-24

Applicant: Oxford University Innovation Limited ,  U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT

Inventor： Richard Lewis Veech ,  Michael Todd King ,  Kieran Clarke

IPC: C12P7/625 ,  C07H13/04 ,  C12P7/26 ,  C07C51/09 ,  C08G63/06 ,  C12P7/62 ,  C07C69/675

Abstract: Novel compounds and compositions containing (R)-3-hydroxybutyrate derivatives are disclosed. The compounds and compositions can be used as nutritional supplements to increase physical performance and as therapeutics to ameliorate symptoms of medical conditions, particularly neurological conditions, such as Alzheimer's and similar conditions. Novel methods for making R-3-hydroxybutyrate derivatives also are disclosed. Exemplary methods employ a supercritical solvent, such as supercritical carbon dioxide, and employ a lipase catalyzed esterification or transesterification reaction to produce the (R)-3-hydroxybutyrate derivatives.

公开(公告)号：US11161798B2

公开(公告)日：2021-11-02

申请号：US16739422

申请日：2020-01-10

Applicant: Concert Pharmaceuticals, Inc.

Inventor： Roger D. Tung

IPC: A61K31/19 ,  A61K31/197 ,  C07C59/01 ,  A61K31/381 ,  A61K45/06 ,  C07B59/00 ,  C07C69/675 ,  A61K31/195

Abstract: This invention relates to novel derivatives of 4-hydroxybutyric acid and prodrugs thereof, and pharmaceutically acceptable salts of the foregoing. This invention also provides pharmaceutical compositions comprising a compound of this invention and the use of such compositions in methods of treating narcolepsy, fibromyalgia, other disorders or conditions that are beneficially treated by improving nocturnal sleep or by administering sodium oxybate.

公开(公告)号：US11136528B2

公开(公告)日：2021-10-05

申请号：US16077358

申请日：2017-10-23

Applicant: Indorama Ventures Oxides LLC

Inventor： Heather Byrne ,  George Smith ,  Hungchang Calvin Chiu ,  Jeffery Cellura ,  Xiaohua Fang ,  Anabel Rubio ,  Matthew T. Meredith

IPC: C11C3/06 ,  C04B26/18 ,  A01N25/00 ,  C11D3/37 ,  C10M145/22 ,  C07C69/675

Abstract: A method of reacting castor oil and an alkoxylated glycerin via a transesterification reaction to produce an estolide of castor oil alkoxylate. Compositions comprising an estolide of castor oil alkoxylate and uses thereof.

公开(公告)号：US11066359B2

公开(公告)日：2021-07-20

申请号：US16484817

申请日：2018-02-08

Applicant: LAWRENCE LIVERMORE NATIONAL SECURITY, LLC

Inventor： Mathew Gerald Lyman ,  Lawrence Dugan ,  Roald N. Leif ,  Bonnee Rubinfeld ,  Brian E. Souza ,  Carlos A. Valdez

IPC: C07C305/06 ,  C07C69/675 ,  C07C69/708

Abstract: Biodegradable surfactants are described, in which an amphiphilic heteroatom containing hydrocarbon optionally comprising at least one counterion (Z), and related compositions, methods and systems. Biodegradable surfactant described herein has an aHLB value in accordance with equation (1): aHLB=20*Gh/(Gh−Gt) (1) wherein Gh is the Group Number of a hydrophilic head portion of the biodegradable surfactant optionally comprising the at least one counterion (Z), and Gt is the Group Number of a hydrophobic tail portion of the biodegradable surfactant. A biodegradable surfactant in the sense of the disclosure can be tuned to a set hydrophilic-lipophilic balance (aHLB) by selectively modifying at least one tuning moiety of the biodegradable surfactants to provide tuned biodegradable surfactants having an increase or decrease in their adjusted hydrophilic-lipophilic balance (aHLB).

公开(公告)号：US11053186B2

公开(公告)日：2021-07-06

申请号：US16839971

申请日：2020-04-03

Applicant: Johnson Matthey Davy Technologies Limited

Inventor： Dena Roberts ,  David John Watson ,  John Swinney

IPC: C07C51/12 ,  C07C67/08 ,  C07C67/54 ,  C07C51/09 ,  C07C59/06 ,  C07C69/675

Abstract: A process for the production of glycolic acid or a derivative thereof comprises: reacting formaldehyde with carbon monoxide and water in a carbonylation reactor in the presence of a sulfur catalyst, said reactor operating under suitable conditions, such that glycolic acid is formed; recovering a first product stream comprising glycolic acid, impurities and a sulfur species in the carbonylation reactor; passing the first product stream to an esterification reactor where it is subjected to esterification to form an alkylglycolate and wherein the esterification is catalysed by the sulfur species recovered in the first product stream; recovering a second product stream comprising the alkylglycolate, sulfur species and impurities from the esterification reactor; separating the sulfur species from the second product stream and recycling it to the carbonylation reactor in step (a) to form a sulphur depleted second product stream; separating the alkylglycolate from the sulphur depleted second product stream in a distillation zone; and recovering the alkylglycolate and converting the alkylglycolate to glycolic acid.