发明申请
- 专利标题： Compositions and methods for systemic nucleic acid sequence delivery
- 专利标题（中）： 全身核酸序列递送的组合物和方法
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申请号： US10988723申请日： 2004-11-15
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公开(公告)号： US20050158281A1公开(公告)日： 2005-07-21
- 发明人: Jeffrey Chamberlain , Paul Gregorevic , Michael Blankinship , James Allen
- 申请人： Jeffrey Chamberlain , Paul Gregorevic , Michael Blankinship , James Allen
- 申请人地址： US WA Seattle
- 专利权人： The University of Washington
- 当前专利权人： The University of Washington
- 当前专利权人地址： US WA Seattle
- 主分类号： A01N43/04
- IPC分类号： A01N43/04 ; A61K31/70 ; A61K48/00 ; C12N15/861 ; C12Q20060101
摘要：
The present invention provides systemic nucleic acid sequence delivery without conventional systemic administration aids (SAAs). In certain embodiments, vascular permeability agents (VPAs), such as VEGF, are used in conjunction with nucleic acid viral vectors, such as adeno-associated virus (AAV). The present invention also provides methods of treating disease by co-administration of nucleic cid sequences encoding Igf-1 and dystrophin or dystrophin-like proteins.
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