发明申请
- 专利标题： Compositons and methods for detection and treatment of proliferative abnormalities associated with overexpression of human transketolase like-1 gene
- 专利标题（中）： 用于检测和治疗与人类转酮酶样-1基因过表达相关的增殖异常的复合物和方法
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申请号： US10511813申请日： 2003-04-12
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公开(公告)号： US20050158726A1公开(公告)日： 2005-07-21
- 发明人: Johannes Coy
- 申请人： Johannes Coy
- 优先权： EP02008831.6 20020419
- 国际申请： PCT/EP03/03827 WO 20030412
- 主分类号： G01N33/53
- IPC分类号： G01N33/53 ; A61K31/7088 ; A61K38/00 ; A61K39/00 ; A61K45/00 ; A61K48/00 ; A61P35/00 ; C12N15/09 ; C12Q1/02 ; C12Q1/68 ; G01N21/78 ; G01N33/566 ; G01N33/58 ; C07K16/40 ; G01N33/574
摘要：
The present invention relates to methods for treatment and diagnosis of disorders associated with abnormally proliferating cells. In one aspect the invention relates to methods, which are especially useful for the detection of tumors and their precursory stages based on the detection of overexpression of human transketolase like-1 gene in biological samples. In another aspect the invention relates to methods for treatment of disorders associated with the overexpression of human transketolase like-1 gene. Methods for treatment may include gene therapeutic approaches as well as methods for inhibiting or reducing the activity of transketolase like-1 polypeptides.
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