发明申请
US20050171005A1 Methods and compositions for modulating beta-catenin phosphorylation
审中-公开
调节β-连环蛋白磷酸化的方法和组合物
- 专利标题： Methods and compositions for modulating beta-catenin phosphorylation
- 专利标题（中）： 调节β-连环蛋白磷酸化的方法和组合物
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申请号： US10972921申请日： 2004-10-25
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公开(公告)号： US20050171005A1公开(公告)日： 2005-08-04
- 发明人: Yinon Ben-Neriah , Irit Alkalay , Sharon Amit , Yaara Birman , Ada Hatzubai
- 申请人： Yinon Ben-Neriah , Irit Alkalay , Sharon Amit , Yaara Birman , Ada Hatzubai
- 优先权： IL149404 20020429
- 主分类号： A61K31/366
- IPC分类号： A61K31/366 ; A61K38/00 ; A61K38/17 ; A61K38/18 ; A61K38/46
摘要：
The present invention provides modulators of β-catenin phosphorylation. More specifically, the present invention provides inhibitors and enhancers of β-catenin Serine 45 (S45) phosphorylation. Examples of inhibitors provided by the invention are the proteins Dishevelled (Dvl), Wnt, phosphatase PP2A and CKI7. Examples of enhancers of beta-catenin phosphorylation are phosphatase inhibitors and proteins that promote β-catenin acetylation, like FRAT1. In addition, the present invention provides compositions and uses of the modulators of the invention, specifically for the treatment of cancer, as well as a method for screening such modulators.
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