Methods and compositions for modulating beta-catenin phosphorylation
    1.
    发明申请
    Methods and compositions for modulating beta-catenin phosphorylation 审中-公开
    调节β-连环蛋白磷酸化的方法和组合物

    公开(公告)号:US20050171005A1

    公开(公告)日:2005-08-04

    申请号:US10972921

    申请日:2004-10-25

    摘要: The present invention provides modulators of β-catenin phosphorylation. More specifically, the present invention provides inhibitors and enhancers of β-catenin Serine 45 (S45) phosphorylation. Examples of inhibitors provided by the invention are the proteins Dishevelled (Dvl), Wnt, phosphatase PP2A and CKI7. Examples of enhancers of beta-catenin phosphorylation are phosphatase inhibitors and proteins that promote β-catenin acetylation, like FRAT1. In addition, the present invention provides compositions and uses of the modulators of the invention, specifically for the treatment of cancer, as well as a method for screening such modulators.

    摘要翻译: 本发明提供β-连环蛋白磷酸化的调节剂。 更具体地,本发明提供β-连环蛋白丝氨酸45(S45)磷酸化的抑制剂和增强剂。 本发明提供的抑制剂的实例是蛋白质紊乱(Dv1),Wnt,磷酸酶PP2A和CKI7。 β-连环蛋白磷酸化增强剂的实例是促进β-连环蛋白乙酰化的磷酸酶抑制剂和蛋白质,如FRAT1。 此外,本发明提供了本发明的调节剂,特别是用于治疗癌症的组合物和用途,以及筛选这些调节剂的方法。